Lawrence J Shimkets
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Explore the profile of Lawrence J Shimkets including associated specialties, affiliations and a list of published articles.
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31
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664
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Recent Articles
1.
Zhang Z, Cotter C, Lyu Z, Shimkets L, Igoshin O
mSystems
. 2020 Jul;
5(4).
PMID: 32665330
Single mutations frequently alter several aspects of cell behavior but rarely reveal whether a particular statistically significant change is biologically significant. To determine which behavioral changes are most important for...
2.
Zhang Z, Igoshin O, Cotter C, Shimkets L
Biophys J
. 2018 Dec;
115(12):2499-2511.
PMID: 30514635
Myxococcus xanthus is a soil bacterium that serves as a model system for biological self-organization. Cells form distinct, dynamic patterns depending on environmental conditions. An agent-based model was used to...
3.
Esquilin-Lebron K, Boynton T, Shimkets L, Thomas M
J Bacteriol
. 2018 Aug;
200(21).
PMID: 30126939
One mechanism by which bacteria and fungi produce bioactive natural products is the use of nonribosomal peptide synthetases (NRPSs). Many NRPSs in bacteria require members of the MbtH-like protein (MLP)...
4.
Bullock H, Shen H, Boynton T, Shimkets L
J Bacteriol
. 2018 Mar;
200(10).
PMID: 29507089
cells produce lipid bodies containing triacylglycerides during fruiting body development. Fatty acid β-oxidation is the most energy-efficient pathway for lipid body catabolism. In this study, we used mutants in (MXAN_5371...
5.
Cotter C, Schuttler H, Igoshin O, Shimkets L
Proc Natl Acad Sci U S A
. 2017 May;
114(23):E4592-E4601.
PMID: 28533367
Collective cell movement is critical to the emergent properties of many multicellular systems, including microbial self-organization in biofilms, embryogenesis, wound healing, and cancer metastasis. However, even the best-studied systems lack...
6.
Bhat S, Boynton T, Pham D, Shimkets L
PLoS One
. 2014 Jun;
9(6):e99622.
PMID: 24906161
Myxococcus xanthus responds to amino acid limitation by producing fruiting bodies containing dormant spores. During development, cells produce triacylglycerides in lipid bodies that become consumed during spore maturation. As the...
7.
Perez J, Jimenez-Zurdo J, Martinez-Abarca F, Millan V, Shimkets L, Munoz-Dorado J
Environ Microbiol
. 2014 Apr;
16(7):2341-50.
PMID: 24707988
Myxococcus xanthus is a social bacterium that preys on prokaryotic and eukaryotic microorganisms. Co-culture of M. xanthus with reference laboratory strains and field isolates of the legume symbiont Sinorhizobium meliloti...
8.
Bhat S, Ahrendt T, Dauth C, Bode H, Shimkets L
mBio
. 2014 Feb;
5(1):e00939-13.
PMID: 24520059
Unlabelled: Myxococcus xanthus produces several extracellular signals that guide fruiting body morphogenesis and spore differentiation. Mutants defective in producing a signal may be rescued by codevelopment with wild-type cells or...
9.
Sanchez-Sutil M, Perez J, Gomez-Santos N, Shimkets L, Moraleda-Munoz A, Munoz-Dorado J
PLoS One
. 2013 Jul;
8(7):e68240.
PMID: 23874560
Myxococcus xanthus is a soil-dwelling member of the δ-Proteobacteria that exhibits a complex developmental cycle upon starvation. Development comprises aggregation and differentiation into environmentally resistant myxospores in an environment that...
10.
Boynton T, McMurry J, Shimkets L
Mol Microbiol
. 2013 Feb;
87(6):1267-76.
PMID: 23369184
During development, Myxococcus xanthus cells undergo programmed cell death (PCD) whereby 80% of vegetative cells die. Previously, the MazF RNA interferase has been implicated in this role. Recently, it was...