Laurent Schaeffer
Overview
Explore the profile of Laurent Schaeffer including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
90
Citations
1917
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Picard F, Nonaka T, Belotti E, Osseni A, Errazuriz-Cerda E, Jost-Mousseau C, et al.
Cell Mol Life Sci
. 2025 Feb;
82(1):76.
PMID: 39948244
Proteinopathies, such as amyotrophic lateral sclerosis (ALS), are marked by the accumulation of misfolded proteins that disrupt cellular processes. Eukaryotic cells have developed protein quality control systems to eliminate these...
2.
Halegua T, Risson V, Carras J, Rouyer M, Coudert L, Jacquier A, et al.
Nat Commun
. 2025 Jan;
16(1):397.
PMID: 39755699
Prime Editing can rewrite genes in living cells by allowing point mutations, deletions, or insertion of small DNA sequences with high precision. However, its safe and efficient delivery into human...
3.
Osseni A, Schaeffer L
Acta Physiol (Oxf)
. 2024 Dec;
241(1):e14256.
PMID: 39676737
No abstract available.
4.
Soendenbroe C, Schjerling P, Bechshoft C, Svensson R, Schaeffer L, Kjaer M, et al.
Aging Cell
. 2024 Nov;
24(3):e14413.
PMID: 39555723
Exercise preserves neuromuscular function in aging through unknown mechanisms. Skeletal muscle fibroblasts (FIB) and stem cells (MuSC) are abundant in skeletal muscle and reside close to neuromuscular junctions, but their...
5.
Lessard L, Girard E, Streichenberger N, Petiot P, Acquaviva C, Pagan C, et al.
Neuromuscul Disord
. 2024 Nov;
45:105235.
PMID: 39509867
We aimed to evaluate whether inherited mitochondrial dysfunction is associated with neuromuscular junction remodeling in patients with mitochondrial disorders. Muscle biopsies from 15 patients with mitochondrial disorders and 10 control...
6.
Fer M, Amalric C, Arban R, Baron L, Ben Hamida S, Breh-Schlanser P, et al.
J Med Chem
. 2024 Jul;
67(13):11296-11325.
PMID: 38949964
Decreased activity and expression of the G-protein coupled receptor GPR88 is linked to many behavior-linked neurological disorders. Published preclinical GPR88 allosteric agonists all have pharmacokinetic properties that preclude their progression...
7.
Mouradian S, Cicciarello D, Lacoste N, Risson V, Berretta F, Le Grand F, et al.
Nucleic Acids Res
. 2024 Feb;
52(7):3667-3681.
PMID: 38321961
The Wnt/β-Catenin pathway plays a key role in cell fate determination during development and in adult tissue regeneration by stem cells. These processes involve profound gene expression and epigenome remodeling...
8.
Belotti E, Lacoste N, Iftikhar A, Simonet T, Papin C, Osseni A, et al.
Nucleic Acids Res
. 2024 Jan;
52(6):3031-3049.
PMID: 38281187
Histone variants are key epigenetic players, but their functional and physiological roles remain poorly understood. Here, we show that depletion of the histone variant H2A.Z in mouse skeletal muscle causes...
9.
Zibold J, Lessard L, Picard F, da Silva L, Zadorozhna Y, Streichenberger N, et al.
Brain
. 2023 Dec;
147(5):1768-1783.
PMID: 38079474
TAR DNA binding protein of 43 kDa (TDP-43)-positive inclusions in neurons are a hallmark of several neurodegenerative diseases including familial amyotrophic lateral sclerosis (fALS) caused by pathogenic TARDBP variants as...
10.
Lequain H, Degletagne C, Streichenberger N, Valantin J, Simonet T, Schaeffer L, et al.
Cells
. 2023 Dec;
12(23).
PMID: 38067175
Sarcoidosis is a multisystemic disease characterized by non-caseating granuloma infiltrating various organs. The form with symptomatic muscular involvement is called muscular sarcoidosis. The impact of immune cells composing the granuloma...