Laurent B Nicolas
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Explore the profile of Laurent B Nicolas including associated specialties, affiliations and a list of published articles.
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16
Citations
163
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Recent Articles
1.
Schaffler K, Nicolas L, Borta A, Brand T, Reitmeir P, Roebling R, et al.
Br J Clin Pharmacol
. 2017 Feb;
83(7):1424-1435.
PMID: 28139023
Aims: The aim of the present study was to assess the predictivity of laser-(radiant-heat)-evoked potentials (LEPs) from the vertex electroencephalogram, using an algesimetric procedure, testing the anti-nociceptive/anti-hyperalgesic effects of single...
2.
Dingemanse J, Nicolas L, van Bortel L
Clin Pharmacol Drug Dev
. 2016 Apr;
2(2):113-9.
PMID: 27121666
This open-label, randomized study evaluated the effects of steady-state diltiazem on the pharmacokinetic, safety, and tolerability profile of a single dose of the novel renin inhibitor ACT-077825. Twelve healthy Caucasian...
3.
Dingemanse J, Nicolas L, van Bortel L
Eur J Clin Pharmacol
. 2014 Apr;
70(6):675-84.
PMID: 24728182
Purpose: ACT-178882, a direct renin inhibitor, was used as a model compound in an elaborate drug-drug interaction study with atorvastatin and simvastatin to explore complex CYP3A4 inductive and inhibitory properties....
4.
Gutierrez M, Nicolas L, Donazzolo Y, Dingemanse J
Int J Clin Pharmacol Ther
. 2013 Apr;
51(6):529-36.
PMID: 23611572
What Is Known: Bosentan is a dual endothelin receptor antagonist approved for the treatment of pulmonary arterial hypertension (PAH). Since bosentan is frequently used to treat pediatric PAH patients, a...
5.
Nicolas L, Gutierrez M, Dingemanse J
Clin Ther
. 2013 Mar;
35(4):440-9.
PMID: 23498778
Background: Epoprostenol sodium for injection is approved for the treatment of severe cases of primary pulmonary arterial hypertension. Currently, there are 3 approved formulations of this drug containing the same...
6.
Nicolas L, Gutierrez M, Binkert C, Dingemanse J
J Cardiovasc Pharmacol
. 2012 Oct;
61(1):42-50.
PMID: 23052033
This study was conducted to characterize the multiple-dose tolerability, pharmacokinetics, and pharmacodynamics of ACT-077825, a new direct renin inhibitor, in healthy male subjects. In this single-center, double-blind, placebo-controlled, active-controlled (20...
7.
Enzler M, Schipp S, Nicolas L, Dingemanse J, Siethoff C
J Chromatogr B Analyt Technol Biomed Life Sci
. 2012 Jul;
901:67-71.
PMID: 22762914
An HPLC-MS/MS method was developed and validated for the quantification of 6-keto prostaglandin F1α, the stable hydrolysis product of prostacyclin, and its metabolites 2,3-dinor-6-keto prostaglandin F1α and 6,15-diketo-13,14-dihydro prostaglandin F1α...
8.
Nicolas L, Krause A, Gutierrez M, Dingemanse J
Br J Clin Pharmacol
. 2012 Apr;
74(6):978-89.
PMID: 22515646
Aim: The aim of the study was to report the first thorough characterization of the pharmacokinetics (PK) and pharmacodynamics (PD) of epoprostenol in an integrated manner. Method: Twenty healthy male...
9.
Nicolas L, Gutierrez M, Binkert C, Dingemanse J
Eur J Clin Pharmacol
. 2012 Mar;
68(9):1257-66.
PMID: 22418829
Purpose: To evaluate the pharmacokinetics, pharmacodynamics, safety, and tolerability of escalating single oral doses of ACT-077825, a novel orally active renin inhibitor, in healthy male subjects. Methods: In this single-center,...
10.
Prinssen E, Nicolas L, Klein S, Grundschober C, Lopez-Lopez C, Kessler M, et al.
Eur Neuropsychopharmacol
. 2011 Dec;
22(6):441-51.
PMID: 22153786
Functional magnetic resonance imaging (fMRI) has become an important method in clinical psychiatry research whereas there are still only few comparable preclinical investigations. Herein, we report that fMRI in rats...