Laurence Tiley
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Explore the profile of Laurence Tiley including associated specialties, affiliations and a list of published articles.
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Articles
11
Citations
329
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Recent Articles
1.
McCallum K, Stubbs S, Hope N, Mickleburgh I, Dight D, Tiley L, et al.
J Vet Intern Med
. 2018 Mar;
32(3):1100-1108.
PMID: 29572949
Background: Feline morbillivirus (FeMV) is associated with the presence of tubulo-interstitial nephritis (TIN) in cats, however the seroprevalence of FeMV in the UK and the association between the presence of...
2.
Bourret V, Croville G, Mariette J, Klopp C, Bouchez O, Tiley L, et al.
Infect Genet Evol
. 2013 May;
18:31-41.
PMID: 23660486
We studied the sub-population level evolution of a duck influenza A virus isolate during passage in swine tracheal cells. The complete genomes of the A/mallard/Netherlands/10-Nmkt/1999 strain and its swine cell-passaged...
3.
Bourret V, Lyall J, Ducatez M, Guerin J, Tiley L
BMC Biotechnol
. 2012 Sep;
12:69.
PMID: 23009349
Background: Virus rescue from transfected cells is an extremely useful technique that allows defined viral clones to be engineered for the purpose of rational vaccine design or fundamental reverse genetics...
4.
Bexfield N, Watson P, Aguirre-Hernandez J, Sargan D, Tiley L, Heeney J, et al.
PLoS One
. 2012 Aug;
7(8):e42584.
PMID: 22870335
Chronic hepatitis (CH) is common in dogs in the United Kingdom. An increased prevalence of the disease is seen in the English Springer spaniel (ESS), and this breed suffer from...
5.
Daly G, Bexfield N, Heaney J, Stubbs S, Mayer A, Palser A, et al.
PLoS One
. 2012 Jan;
6(12):e28879.
PMID: 22216131
Here we describe a virus discovery protocol for a range of different virus genera, that can be applied to biopsy-sized tissue samples. Our viral enrichment procedure, validated using canine and...
6.
Lyall J, Irvine R, Sherman A, McKinley T, Nunez A, Purdie A, et al.
Science
. 2011 Jan;
331(6014):223-6.
PMID: 21233391
Infection of chickens with avian influenza virus poses a global threat to both poultry production and human health that is not adequately controlled by vaccination or by biosecurity measures. A...
7.
Mickleburgh I, Geng F, Tiley L
Antivir Chem Chemother
. 2009 Jun;
19(5):213-8.
PMID: 19483269
Background: An unusual feature of influenza viral -messenger RNA (mRNA) synthesis is its dependence upon host cell mRNAs as a source of capped RNA primers. A crucial activity of the...
8.
Gog J, Santos Afonso E, Dalton R, Leclercq I, Tiley L, Elton D, et al.
Nucleic Acids Res
. 2007 Mar;
35(6):1897-907.
PMID: 17332012
Genome segmentation facilitates reassortment and rapid evolution of influenza A virus. However, segmentation complicates particle assembly as virions must contain all eight vRNA species to be infectious. Specific packaging signals...
9.
Lee M, Klumpp K, Digard P, Tiley L
Nucleic Acids Res
. 2003 Mar;
31(6):1624-32.
PMID: 12626703
The current model for influenza virus mRNA transcription involves the sequential interaction of the viral polymerase with the 5'- and 3'-ends of vRNA, with each RNA-protein interaction triggering a polymerase...
10.
Tiley L, King A, Belsham G
J Virol
. 2003 Jan;
77(3):2243-6.
PMID: 12525659
A temperature-sensitive (ts) mutation was identified within the 5'-untranslated region of foot-and-mouth disease virus (FMDV) RNA. The mutation destabilizes a stem-loop structure recently identified as a cis-acting replication element (cre)....