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Lauren Switala

Explore the profile of Lauren Switala including associated specialties, affiliations and a list of published articles. Areas
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Recent Articles
1.
Switala L, Di L, Colantonio S, Lakshman B, Caceres T, Reading J, et al.
ACS Omega . 2025 Jan; 10(1):1110-1121. PMID: 39829496
We have developed two monoclonal antibodies, CPTC-2MeSC-1 and CPTC-2MeSC-2, against itaconate and its conjugates with sulfhydryl-containing biomolecules such as cysteines. Itaconate is a dicarboxylic acid metabolite that has recently gained...
2.
Switala L, Di L, Gao H, Asase C, Klos M, Rengasamy P, et al.
J Nanobiotechnology . 2024 May; 22(1):223. PMID: 38702815
Cardiac muscle targeting is a notoriously difficult task. Although various nanoparticle (NP) and adeno-associated viral (AAV) strategies with heart tissue tropism have been developed, their performance remains suboptimal. Significant off-target...
3.
Di L, Thomas A, Switala L, Kalikasingh K, Lapping S, Nayak L, et al.
Nano Lett . 2023 Oct; 23(21):9690-9696. PMID: 37884274
Antiphospholipid syndrome (APS) is an autoimmune disease characterized by recurrent arterial, venous, and microvascular thrombosis where activated neutrophils play a determinant role. However, neutrophils are challenging to target given their...
4.
Shepard K, Vodak D, Kuehl P, Revelli D, Zhou Y, Pluntze A, et al.
AAPS PharmSciTech . 2021 Sep; 22(7):230. PMID: 34467438
Local delivery of biotherapeutics to the lung holds great promise for treatment of lung diseases, but development of physically stable, biologically active dry powder formulations of large molecules for inhalation...