Lauren J Lahey
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Explore the profile of Lauren J Lahey including associated specialties, affiliations and a list of published articles.
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25
Citations
1339
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Recent Articles
1.
Brewer R, Ramadoss N, Lahey L, Jahanbani S, Robinson W, Lanz T
Nat Immunol
. 2021 Dec;
23(1):33-39.
PMID: 34848871
The first ever US Food and Drug Administration-approved messenger RNA vaccines are highly protective against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, the contribution of each dose to the...
2.
Lahey L, Mardjuki R, Wen X, Hess G, Ritchie C, Carozza J, et al.
Mol Cell
. 2020 Nov;
80(4):578-591.e5.
PMID: 33171122
Extracellular 2'3'-cyclic-GMP-AMP (cGAMP) is an immunotransmitter exported by diseased cells and imported into host cells to activate the innate immune STING pathway. We previously identified SLC19A1 as a cGAMP importer,...
3.
Kuerten S, Lanz T, Lingampalli N, Lahey L, Kleinschnitz C, Maurer M, et al.
Proc Natl Acad Sci U S A
. 2020 Aug;
117(35):21512-21518.
PMID: 32817492
Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system (CNS), with characteristic inflammatory lesions and demyelination. The clinical benefit of cell-depleting therapies targeting CD20 has emphasized...
4.
Ho P, Lahey L, Mourkioti F, Kraft P, Filareto A, Brandt M, et al.
Proc Natl Acad Sci U S A
. 2018 Sep;
115(39):E9182-E9191.
PMID: 30181272
In gene therapy for Duchenne muscular dystrophy there are two potential immunological obstacles. An individual with Duchenne muscular dystrophy has a genetic mutation in dystrophin, and therefore the wild-type protein...
5.
Lingampalli N, Sokolove J, Lahey L, Edison J, Gilliland W, Holers V, et al.
Clin Immunol
. 2018 May;
195:119-126.
PMID: 29842946
The development of rheumatoid factor (RF) and/or anti-citrullinated protein antibodies (ACPAs) can be observed years prior to clinical diagnosis of rheumatoid arthritis (RA). Nevertheless, the interaction between these two autoantibodies...
6.
Blum L, Cao R, Sweatt A, Bill M, Lahey L, Hsi A, et al.
Eur J Immunol
. 2018 Jan;
48(5):874-884.
PMID: 29369345
Idiopathic pulmonary arterial hypertension (IPAH) is a devastating pulmonary vascular disease in which autoimmune and inflammatory phenomena are implicated. B cells and autoantibodies have been associated with IPAH and identified...
7.
Demoruelle M, Bowers E, Lahey L, Sokolove J, Purmalek M, Seto N, et al.
Arthritis Rheumatol
. 2017 Dec;
70(4):516-527.
PMID: 29266801
Objective: The location and mechanisms involved in the initial generation of autoantibodies to citrullinated and noncitrullinated proteins/peptides during the natural history of rheumatoid arthritis (RA) development is incompletely understood. This...
8.
Hejblum B, Cui J, Lahey L, Cagan A, Sparks J, Sokolove J, et al.
Arthritis Care Res (Hoboken)
. 2017 Oct;
70(7):1113-1117.
PMID: 28992379
Objective: Antibodies against citrullinated fibrinogen (anti-Cit-fibrinogen) have been implicated in rheumatoid arthritis (RA) and associated with cardiovascular risk in RA. The objective of this study was to examine the association...
9.
Liao K, Sparks J, Hejblum B, Kuo I, Cui J, Lahey L, et al.
Arthritis Rheumatol
. 2016 Oct;
69(4):742-749.
PMID: 27792870
Objective: Patients with rheumatoid arthritis (RA) develop autoantibodies against a spectrum of antigens, but the clinical significance of these autoantibodies is unclear. Using a phenome-wide association study (PheWAS) approach, we...
10.
Tajerian M, Hung V, Khan H, Lahey L, Sun Y, Birklein F, et al.
Exp Neurol
. 2016 Oct;
287(Pt 1):14-20.
PMID: 27773721
Objective: Using a mouse model of complex regional pain syndrome (CRPS), our goal was to identify autoantigens in the skin of the affected limb. Methods: A CRPS-like state was induced...