Lauren Blair Woods
Overview
Explore the profile of Lauren Blair Woods including associated specialties, affiliations and a list of published articles.
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Articles
3
Citations
44
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Recent Articles
1.
Schlegel M, Janas M, Jiang Y, Barry J, Davis W, Agarwal S, et al.
Nucleic Acids Res
. 2022 Jun;
50(12):6656-6670.
PMID: 35736224
Preclinical mechanistic studies have pointed towards RNA interference-mediated off-target effects as a major driver of hepatotoxicity for GalNAc-siRNA conjugates. Here, we demonstrate that a single glycol nucleic acid or 2'-5'-RNA...
2.
Akabane-Nakata M, Erande N, Kumar P, Degaonkar R, Gilbert J, Qin J, et al.
Nucleic Acids Res
. 2021 Feb;
49(5):2435-2449.
PMID: 33577685
We recently reported the synthesis of 2'-fluorinated Northern-methanocarbacyclic (2'-F-NMC) nucleotides, which are based on a bicyclo[3.1.0]hexane scaffold. Here, we analyzed RNAi-mediated gene silencing activity in cell culture and demonstrated that...
3.
Mikami A, Erande N, Matsuda S, Kelin A, Woods L, Chickering T, et al.
Nucleic Acids Res
. 2020 Sep;
48(18):10101-10124.
PMID: 32990754
Various chemical modifications have been identified that enhance potency of small interfering RNAs (siRNAs) and that reduce off-target effects, immune stimulation, and toxicities of metabolites of these therapeutic agents. We...