Laure Guenin-Mace
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Explore the profile of Laure Guenin-Mace including associated specialties, affiliations and a list of published articles.
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22
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572
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Recent Articles
1.
Berger S, Seeger F, Yu T, Aydin M, Yang H, Rosenblum D, et al.
Cell
. 2024 Jun;
187(16):4305-4317.e18.
PMID: 38936360
Interleukin (IL)-23 and IL-17 are well-validated therapeutic targets in autoinflammatory diseases. Antibodies targeting IL-23 and IL-17 have shown clinical efficacy but are limited by high costs, safety risks, lack of...
2.
Guenin-Mace L, Konieczny P, Naik S
Annu Rev Immunol
. 2023 Jan;
41:207-228.
PMID: 36696569
The epithelial tissues that line our body, such as the skin and gut, have remarkable regenerative prowess and continually renew throughout our lifetimes. Owing to their barrier function, these tissues...
3.
Laval T, Pedro-Cos L, Malaga W, Guenin-Mace L, Pawlik A, Mayau V, et al.
Elife
. 2021 Dec;
10.
PMID: 34951591
Successful control of (Mtb) infection by macrophages relies on immunometabolic reprogramming, where the role of fatty acids (FAs) remains poorly understood. Recent studies unraveled Mtb's capacity to acquire saturated and...
4.
Rifflet A, Demangel C, Guenin-Mace L
Methods Mol Biol
. 2021 Oct;
2387:117-130.
PMID: 34643908
Mycolactones are a family of polyketide synthase products made by the human pathogen Mycobacterium ulcerans that were recently identified as novel inhibitors of the host membrane translocation complex (Sec61). Here,...
5.
Rubio B, Bugault F, Baudon B, Raynal B, Brule S, Morel J, et al.
Front Pharmacol
. 2021 Oct;
12:733496.
PMID: 34603049
Mycolactone is a diffusible lipid toxin produced by the causative agent of Buruli ulcer disease. Altough bacterially derived mycolactone has been shown to traffic from cutaneous foci of infection to...
6.
Chevalier G, Siopi E, Guenin-Mace L, Pascal M, Laval T, Rifflet A, et al.
Nat Commun
. 2020 Dec;
11(1):6363.
PMID: 33311466
Depression is the leading cause of disability worldwide. Recent observations have revealed an association between mood disorders and alterations of the intestinal microbiota. Here, using unpredictable chronic mild stress (UCMS)...
7.
Colucci-Guyon E, Rifflet A, Saint-Auret S, da Costa A, Boucontet L, Laval T, et al.
PLoS Negl Trop Dis
. 2020 Dec;
14(12):e0008878.
PMID: 33264290
Mycobacterium ulcerans, the causative agent of Buruli ulcer (BU) disease, is unique amongst human pathogens in its capacity to produce a lipid toxin called mycolactone. While previous studies have demonstrated...
8.
Guenin-Mace L, Morel J, Doisne J, Schiavo A, Boulet L, Mayau V, et al.
JCI Insight
. 2020 Sep;
5(20).
PMID: 32970636
Hidradenitis suppurativa (HS) is a chronic skin disorder of unknown etiology that manifests as recurrent, painful lesions. Cutaneous dysbiosis and unresolved inflammation are hallmarks of active HS, but their origin...
9.
Morel J, Paatero A, Wei J, Yewdell J, Guenin-Mace L, Van Haver D, et al.
Mol Cell Proteomics
. 2018 Jun;
17(9):1750-1765.
PMID: 29915147
Mycolactone is a bacteria-derived macrolide that blocks the biogenesis of a large array of secretory and integral transmembrane proteins (TMP) through potent inhibition of the Sec61 translocon. Here, we used...
10.
Isaac C, Mauborgne A, Grimaldi A, Ade K, Pohl M, Limatola C, et al.
PLoS Negl Trop Dis
. 2017 Nov;
11(11):e0006058.
PMID: 29149212
Background: Mycolactone is a macrolide produced by the skin pathogen Mycobacterium ulcerans, with cytotoxic, analgesic and immunomodulatory properties. The latter were recently shown to result from mycolactone blocking the Sec61-dependent...