Laura Xicota
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Explore the profile of Laura Xicota including associated specialties, affiliations and a list of published articles.
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21
Citations
462
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Recent Articles
1.
Liou J, Lou J, Flores-Aguilar L, Nakagiri J, Yong W, Hom C, et al.
Alzheimers Dement
. 2025 Jan;
21(2):e14479.
PMID: 39868632
Introduction: Aging adults with Down syndrome (DS) accumulate Alzheimer's disease (AD) neuropathology, including amyloid beta plaques and neurofibrillary tangles, by age 40. Methods: We present findings from an individual with...
2.
Xicota L, Dang L, Lee A, Krinsky-McHale S, Pang D, Melilli L, et al.
EBioMedicine
. 2024 Nov;
110:105433.
PMID: 39500037
Background: Individuals with Down syndrome (DS) are at high risk of early-onset Alzheimer's disease (AD); yet, some 20 percent do not develop any signs of dementia until after 65 years...
3.
Liou J, Lou J, Nakagiri J, Yong W, Hom C, Doran E, et al.
medRxiv
. 2024 Jun;
PMID: 38883742
In this neuropathology case report, we present findings from an individual with Down syndrome (DS) who remained cognitively stable despite Alzheimer's disease (AD) neuropathology. Clinical assessments, fluid biomarkers, neuroimaging, and...
4.
Eysert F, Kinoshita P, Lagarde J, Lacas-Gervais S, Xicota L, Dorothee G, et al.
Acta Neuropathol Commun
. 2024 Jun;
12(1):90.
PMID: 38851733
Mitochondrial dysfunctions are key features of Alzheimer's disease (AD). The occurrence of these disturbances in the peripheral cells of AD patients and their potential correlation with disease progression are underinvestigated....
5.
Xicota L, Cosentino S, Vardarajan B, Mayeux R, Perls T, Andersen S, et al.
Alzheimers Dement
. 2024 Feb;
20(4):2670-2679.
PMID: 38380866
Introduction: Late-onset Alzheimer's disease (LOAD) has a strong genetic component. Participants in Long-Life Family Study (LLFS) exhibit delayed onset of dementia, offering a unique opportunity to investigate LOAD genetics. Methods:...
6.
Baune B, Minelli A, Carpiniello B, Contu M, Dominguez Barragan J, Donlo C, et al.
Front Psychiatry
. 2024 Feb;
14:1279688.
PMID: 38348362
Major depressive disorder (MDD) is the most common psychiatric disease worldwide with a huge socio-economic impact. Pharmacotherapy represents the most common option among the first-line treatment choice; however, only about...
7.
Xicota L, Lagarde J, Eysert F, Grenier-Boley B, Rivals I, Botte A, et al.
Transl Psychiatry
. 2023 Feb;
13(1):54.
PMID: 36788216
Morphological alterations of the endosomal compartment have been widely described in post-mortem brains from Alzheimer's disease (AD) patients and subjects with Down syndrome (DS) who are at high risk for...
8.
Sathyanarayanan A, Mueller T, Moni M, Schueler K, Baune B, Dierssen M, et al.
Eur Neuropsychopharmacol
. 2023 Jan;
69:26-46.
PMID: 36706689
To study mental illness and health, in the past researchers have often broken down their complexity into individual subsystems (e.g., genomics, transcriptomics, proteomics, clinical data) and explored the components independently....
9.
Xicota L, Gyorgy B, Grenier-Boley B, Lecoeur A, Fontaine G, Danjou F, et al.
Neurology
. 2022 May;
99(5):e462-e475.
PMID: 35606148
Background And Objectives: Brain amyloid deposition, a major risk factor for Alzheimer disease (AD), is currently estimated by measuring CSF or plasma amyloid peptide levels or by PET imaging. Assessing...
10.
Pisanu C, Severino G, De Toma I, Dierssen M, Fusar-Poli P, Gennarelli M, et al.
Eur Neuropsychopharmacol
. 2022 Jan;
55:112-157.
PMID: 35016057
Variation in the expression level and activity of genes involved in drug disposition and action in tissues of pharmacological importance have been increasingly investigated in patients treated with psychotropic drugs....