Laura Torella
Overview
Explore the profile of Laura Torella including associated specialties, affiliations and a list of published articles.
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Articles
7
Citations
70
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0
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Recent Articles
1.
Torella L, Santana-Gonzalez N, Zabaleta N, Aseguinolaza G
FEBS Lett
. 2024 Jul;
598(19):2348-2371.
PMID: 39079936
The deliberate and precise modification of the host genome using engineered nucleases represents a groundbreaking advancement in modern medicine. Several clinical trials employing these approaches to address metabolic liver disorders...
2.
Camps G, Maestro S, Torella L, Herrero D, Usai C, Bilbao-Arribas M, et al.
PLoS Pathog
. 2024 May;
20(5):e1011749.
PMID: 38739648
Hepatitis delta virus (HDV) infection represents the most severe form of human viral hepatitis; however, the mechanisms underlying its pathology remain incompletely understood. We recently developed an HDV mouse model...
3.
Torella L, Klermund J, Bilbao-Arribas M, Tamayo I, Andrieux G, Chmielewski K, et al.
EMBO Mol Med
. 2024 Jan;
16(1):112-131.
PMID: 38182795
The therapeutic use of adeno-associated viral vector (AAV)-mediated gene disruption using CRISPR-Cas9 is limited by potential off-target modifications and the risk of uncontrolled integration of vector genomes into CRISPR-mediated double-strand...
4.
Giorgalli M, Cunningham D, Broncel M, Sait A, Harrison T, Hosking C, et al.
Front Cell Infect Microbiol
. 2022 Jul;
12:877253.
PMID: 35782145
multigene families are thought to play important roles in the pathogenesis of malaria. genes comprise the largest multigene family in many species. However, their expression pattern and localisation remain to...
5.
Zabaleta N, Torella L, Weber N, Gonzalez-Aseguinolaza G
Hepatology
. 2022 Mar;
76(3):869-887.
PMID: 35243655
The efficient delivery of RNA molecules to restore the expression of a missing or inadequately functioning protein in a target cell and the intentional specific modification of the host genome...
6.
Lopez-Manzaneda S, Ojeda-Perez I, Zabaleta N, Garcia-Torralba A, Alberquilla O, Torres R, et al.
Mol Ther Methods Clin Dev
. 2020 Dec;
19:426-437.
PMID: 33294491
The development of advanced gene and cell therapies for the treatment of genetic diseases requires reliable animal and cellular models to test their efficacy. Moreover, the availability of the target...
7.
Zabaleta N, Barberia M, Martin-Higueras C, Zapata-Linares N, Betancor I, Rodriguez S, et al.
Nat Commun
. 2018 Dec;
9(1):5454.
PMID: 30575740
CRISPR/Cas9 technology offers novel approaches for the development of new therapies for many unmet clinical needs, including a significant number of inherited monogenic diseases. However, in vivo correction of disease-causing...