Laura Sieber
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Explore the profile of Laura Sieber including associated specialties, affiliations and a list of published articles.
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15
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2402
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Recent Articles
1.
Bianchini L, Sieber L, Hammad R, Schafer R, Kutscher L
Stem Cell Res
. 2024 Aug;
80:103524.
PMID: 39106599
We generated two human induced pluripotent cell (hiPSC) isogenic clones from an 11-year-old patient with 6q27 deletion syndrome. The heterozygous deletion encompasses approximately 240 kilobases, affecting 6 genes (promoter region...
2.
Loss of Elp1 in cerebellar granule cell progenitors models ataxia phenotype of Familial Dysautonomia
Arnskotter F, da Silva P, Schouw M, Lukasch C, Bianchini L, Sieber L, et al.
Neurobiol Dis
. 2024 Jul;
199:106600.
PMID: 38996985
Familial Dysautonomia (FD) is an autosomal recessive disorder caused by a splice site mutation in the gene ELP1, which disproportionally affects neurons. While classically characterized by deficits in sensory and...
3.
Krausert S, Brabetz S, Mack N, Schmitt-Hoffner F, Schwalm B, Peterziel H, et al.
Neurooncol Adv
. 2022 Apr;
4(1):vdac026.
PMID: 35475274
Background: Inhibition of the sonic hedgehog (SHH) pathway with Smoothened (SMO) inhibitors is a promising treatment strategy in SHH-activated medulloblastoma, especially in adult patients. However, the problem is that tumors...
4.
Kotsougiani-Fischer D, Sieber L, Fischer S, Hirche C, Maraka S, Kneser U
Aesthetic Plast Surg
. 2021 Jan;
45(4):1431-1440.
PMID: 33483783
Background: The aesthetic and functional outcomes of the donor site following abdominal-based free flap breast reconstruction have been suboptimal. The objective of this study is to evaluate a modified liposuction-assisted...
5.
Siegwart L, Sieber L, Fischer S, Maraka S, Kneser U, Kotsougiani-Fischer D
Microsurgery
. 2020 Nov;
42(1):32-39.
PMID: 33201541
Introduction: Closed incision negative-pressure therapy (CINPT) has been shown to shorten the time to heal in post-bariatric abdominoplasty and to lower seroma rates in cosmetic abdominoplasty. The objective of this...
6.
Kutscher L, Okonechnikov K, Batora N, Clark J, Silva P, Vouri M, et al.
Genes Dev
. 2020 Aug;
34(17-18):1161-1176.
PMID: 32820036
Medulloblastoma is a malignant childhood brain tumor arising from the developing cerebellum. In Sonic Hedgehog (SHH) subgroup medulloblastoma, aberrant activation of SHH signaling causes increased proliferation of granule neuron progenitors...
7.
Pajtler K, Wei Y, Okonechnikov K, Silva P, Vouri M, Zhang L, et al.
Nat Commun
. 2019 Sep;
10(1):3914.
PMID: 31477715
YAP1 fusion-positive supratentorial ependymomas predominantly occur in infants, but the molecular mechanisms of oncogenesis are unknown. Here we show YAP1-MAMLD1 fusions are sufficient to drive malignant transformation in mice, and...
8.
Forget A, Martignetti L, Puget S, Calzone L, Brabetz S, Picard D, et al.
Cancer Cell
. 2018 Sep;
34(3):379-395.e7.
PMID: 30205043
The current consensus recognizes four main medulloblastoma subgroups (wingless, Sonic hedgehog, group 3 and group 4). While medulloblastoma subgroups have been characterized extensively at the (epi-)genomic and transcriptomic levels, the...
9.
Feng W, Kawauchi D, Korkel-Qu H, Deng H, Serger E, Sieber L, et al.
Nat Commun
. 2017 Mar;
8:14758.
PMID: 28317875
Mutations in chromatin modifier genes are frequently associated with neurodevelopmental diseases. We herein demonstrate that the chromodomain helicase DNA-binding protein 7 (Chd7), frequently associated with CHARGE syndrome, is indispensable for...
10.
Johann P, Erkek S, Zapatka M, Kerl K, Buchhalter I, Hovestadt V, et al.
Cancer Cell
. 2016 Mar;
29(3):379-393.
PMID: 26923874
Atypical teratoid/rhabdoid tumor (ATRT) is one of the most common brain tumors in infants. Although the prognosis of ATRT patients is poor, some patients respond favorably to current treatments, suggesting...