Laura Lopez-Cruz
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Explore the profile of Laura Lopez-Cruz including associated specialties, affiliations and a list of published articles.
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Articles
32
Citations
632
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Recent Articles
1.
Olivares-Garcia R, Lopez-Cruz L, Carratala-Ros C, Matas-Navarro P, Salamone J, Correa M
Neuropharmacology
. 2024 Oct;
262:110197.
PMID: 39442910
Mesolimbic dopamine (DA) plays a critical role in behavioral activation and exertion of effort in motivated behaviors. DA antagonism and depletion in nucleus accumbens (Nacb) induces anergia in effort-based decision-making...
2.
Foerster S, Floriddia E, van Bruggen D, Kukanja P, Herve B, Cheng S, et al.
Nat Neurosci
. 2024 Jun;
27(8):1545-1554.
PMID: 38849524
In the mouse embryonic forebrain, developmentally distinct oligodendrocyte progenitor cell populations and their progeny, oligodendrocytes, emerge from three distinct regions in a spatiotemporal gradient from ventral to dorsal. However, the...
3.
Reconsidering repurposing: long-term metformin treatment impairs cognition in Alzheimer's model mice
Cho S, Kim E, Park S, Phillips B, Jeong J, Kim H, et al.
Transl Psychiatry
. 2024 Jan;
14(1):34.
PMID: 38238285
Metformin, a primary anti-diabetic medication, has been anticipated to provide benefits for Alzheimer's disease (AD), also known as "type 3 diabetes". Nevertheless, some studies have demonstrated that metformin may trigger...
4.
Lopez-Cruz L, Phillips B, Hailwood J, Saksida L, Heath C, Bussey T
Neuropsychopharmacology
. 2023 Aug;
49(2):422-432.
PMID: 37644210
Effort-based decision-making is impaired in multiple psychopathologies leading to significant impacts on the daily life of patients. Preclinical studies of this important transdiagnostic symptom in rodents are hampered, however, by...
5.
Dutcher E, Lopez-Cruz L, Pama E, Lynall M, Bevers I, Jones J, et al.
Transl Psychiatry
. 2023 Mar;
13(1):81.
PMID: 36882404
Early-life stress (ELS) or adversity, particularly in the form of childhood neglect and abuse, is associated with poor mental and physical health outcomes in adulthood. However, whether these relationships are...
6.
Zuhlsdorff K, Lopez-Cruz L, Dutcher E, Jones J, Pama C, Sawiak S, et al.
Neurobiol Stress
. 2022 Dec;
22:100507.
PMID: 36505960
Major depressive disorder (MDD) is a stress-related condition hypothesized to involve aberrant reinforcement learning (RL) with positive and negative stimuli. The present study investigated whether repeated early maternal separation (REMS)...
7.
Carratala-Ros C, Lopez-Cruz L, Martinez-Verdu A, Olivares-Garcia R, Salamone J, Correa M
Front Behav Neurosci
. 2021 Jul;
15:700182.
PMID: 34305547
Impaired behavioral activation and effort-related motivational dysfunctions like fatigue and anergia are debilitating treatment-resistant symptoms of depression. Depressed people show a bias towards the selection of low effort activities. To...
8.
Lopez-Cruz L, Bussey T, Saksida L, Heath C
Lab Anim (NY)
. 2021 Jun;
50(7):174-184.
PMID: 34140683
Despite considerable advances in both in silico and in vitro approaches, in vivo studies that involve animal model systems remain necessary in many research disciplines. Neuroscience is one such area,...
9.
Porru S, Lopez-Cruz L, Carratala-Ros C, Salamone J, Acquas E, Correa M
Alcohol Clin Exp Res
. 2021 Jan;
45(3):608-619.
PMID: 33471948
Background: Caffeine is frequently consumed with ethanol to reduce the impairing effects induced by ethanol, including psychomotor slowing or incoordination. Both drugs modulate dopamine (DA)-related markers in accumbens (Acb), and...
10.
Kim E, White M, Phillips B, Lopez-Cruz L, Kim H, Heath C, et al.
Transl Psychiatry
. 2020 Nov;
10(1):377.
PMID: 33149110
Perseveration and apathy are two of the most common behavioural and psychological symptoms of dementia (BPSDs) in amyotrophic lateral sclerosis-frontotemporal dementia (ALS-FTD). Availability of a validated and behaviourally characterised animal...