Laura Librizzi
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Explore the profile of Laura Librizzi including associated specialties, affiliations and a list of published articles.
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32
Citations
532
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Recent Articles
1.
Avoli M, Chen L, Di Cristo G, Librizzi L, Scalmani P, Shiri Z, et al.
Neurobiol Dis
. 2023 Mar;
180:106097.
PMID: 36967064
We review here the neuronal mechanisms that cause seizures in focal epileptic disorders and, specifically, those involving limbic structures that are known to be implicated in human mesial temporal lobe...
2.
de Curtis M, Librizzi L, Uva L
Neurobiol Dis
. 2023 Jan;
178:106007.
PMID: 36682502
Epilepsies affecting the limbic regions are common and generate seizures often resistant to pharmacological treatment. Clinical evidence demonstrates that diverse regions of the mesial portion of the temporal lobe participate...
3.
Avoli M, de Curtis M, Levesque M, Librizzi L, Uva L, Wang S
Front Neural Circuits
. 2022 Oct;
16:984802.
PMID: 36275847
Under physiological conditions, neuronal network synchronization leads to different oscillatory EEG patterns that are associated with specific behavioral and cognitive functions. Excessive synchronization can, however, lead to focal or generalized...
4.
Beretta S, Versace A, Fiore G, Piola M, Martini B, Bigiogera V, et al.
Neurotherapeutics
. 2022 Sep;
19(6):1942-1950.
PMID: 36129603
Hypothermia is a promising therapeutic strategy for severe vasospasm and other types of non-thrombotic cerebral ischemia, but its clinical application is limited by significant systemic side effects. We aimed to...
5.
Librizzi L, Uva L, Raspagliesi L, Gionso M, Regondi M, Durando G, et al.
Sci Rep
. 2022 Feb;
12(1):2906.
PMID: 35190597
The blood-brain barrier (BBB) represents a major obstacle to the delivery of drugs to the central nervous system. The combined use of low-intensity pulsed ultrasound waves and intravascular microbubbles (MB)...
6.
Librizzi L, Verde D, Colciaghi F, Deleo F, Regondi M, Costanza M, et al.
Epilepsia
. 2021 Jun;
62(7):1715-1728.
PMID: 34061984
Objective: The influx of immune cells and serum proteins from the periphery into the brain due to a dysfunctional blood-brain barrier (BBB) has been proposed to contribute to the pathogenesis...
7.
Verde D, de Curtis M, Librizzi L
Front Neurol
. 2021 Feb;
12:607603.
PMID: 33574794
It has been proposed that seizures induce IL-1β biosynthesis in astrocytes and increase blood brain barrier (BBB) permeability, even without the presence of blood borne inflammatory molecules and leukocytes. In...
8.
Moroni R, Regondi M, de Curtis M, Frassoni C, Librizzi L
Neuroscience
. 2020 Jun;
441:65-76.
PMID: 32590038
Astrocyte dysfunction, and in particular impaired extracellular potassium spatial buffering, has been postulated to have a potential role in seizure susceptibility and ictogenesis. Inwardly rectifying potassium (Kir) channels, and specifically...
9.
Gnatkovsky V, Cattalini A, Antonini A, Spreafico L, Saini M, Noe F, et al.
Int J Nanomedicine
. 2020 Jan;
14:10079-10089.
PMID: 31920304
Background: Multielectrodes are implanted in central and peripheral nervous systems for rehabilitation and diagnostic purposes. The physical resistance of intracranial devices to mechanical stress is critical and fractures or electrode...
10.
de Curtis M, Librizzi L, Uva L, Gnatkovsky V
Neurobiol Dis
. 2019 Feb;
125:190-197.
PMID: 30742907
Focal seizures are triggered by the pathological synchronization of a functionally altered group of neurons. In vivo and in vitro results in rodents and single unit studies in humans suggest...