Laura Icardi
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Explore the profile of Laura Icardi including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
274
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0
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Recent Articles
1.
Perucho L, Icardi L, Di Simone E, Basso V, Agresti A, Vilas Zornoza A, et al.
EMBO Rep
. 2023 Mar;
24(5):e55326.
PMID: 36929576
The Sin3 transcriptional regulator homolog A (Sin3A) is the core member of a multiprotein chromatin-modifying complex. Its inactivation at the CD4/CD8 double-negative stage halts further thymocyte development. Among various functions,...
2.
Gambi G, Di Simone E, Basso V, Ricci L, Wang R, Verma A, et al.
Cancer Res
. 2019 Jan;
79(12):3076-3087.
PMID: 30692217
Epigenetic silencing of promoter and enhancer regions is a common phenomenon in malignant cells. The transcription factor STAT3 is aberrantly activated in several tumors, where its constitutive acetylation accounts for...
3.
Mori R, Wauman J, Icardi L, Van der Heyden J, De Cauwer L, Peelman F, et al.
Sci Rep
. 2017 Nov;
7(1):15919.
PMID: 29162862
STAT3 is a pleiotropic transcription factor involved in homeostatic and host defense processes in the human body. It is activated by numerous cytokines and growth factors and generates a series...
4.
Mondino A, Vella G, Icardi L
Cytokine Growth Factor Rev
. 2017 Jun;
36:57-65.
PMID: 28629762
Adoptive T cell therapy (ACT) has become a promising immunotherapeutic option for cancer patients. The proof for ACT therapeutic efficacy was first obtained with allogenic T cells and then reproduced...
5.
Bustin S, Benes V, Garson J, Hellemans J, Huggett J, Kubista M, et al.
Nat Methods
. 2013 Nov;
10(11):1063-7.
PMID: 24173381
Two surveys of over 1,700 publications whose authors use quantitative real-time PCR (qPCR) reveal a lack of transparent and comprehensive reporting of essential technical information. Reporting standards are significantly improved...
6.
Icardi L, De Bosscher K, Tavernier J
Cytokine Growth Factor Rev
. 2012 Sep;
23(6):283-91.
PMID: 22989617
Besides the transcription-promoting role of histone acetyltransferases (HATs) and the transcription-delimiting function of histone deacetylases (HDACs) through histone acetylation and deacetylation respectively, HATs and HDACs also regulate the activity of...
7.
Icardi L, Mori R, Gesellchen V, Eyckerman S, De Cauwer L, Verhelst J, et al.
Proc Natl Acad Sci U S A
. 2012 Jul;
109(30):12058-63.
PMID: 22783022
Tyrosine phosphorylation is a hallmark for activation of STAT proteins, but their transcriptional activity also depends on other secondary modifications. Type I IFNs can activate both the ISGF3 (STAT1:STAT2:IRF9) complex...
8.
Icardi L, Lievens S, Mori R, Piessevaux J, De Cauwer L, De Bosscher K, et al.
FASEB J
. 2011 Sep;
26(1):240-9.
PMID: 21957129
The antiviral and antiproliferative responses mediated by type I interferons (IFNs) depend on JAK/STAT signaling and ISGF3 (STAT1:STAT2:IRF9)-dependent transcription. In addition, type I IFNs stimulate STAT3 activation in many cell...