Laura Cracco
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Explore the profile of Laura Cracco including associated specialties, affiliations and a list of published articles.
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19
Citations
186
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Recent Articles
1.
Arseni D, Nonaka T, Jacobsen M, Murzin A, Cracco L, Peak-Chew S, et al.
Nature
. 2024 Sep;
634(8034):662-668.
PMID: 39260416
Neurodegenerative diseases are characterized by the abnormal filamentous assembly of specific proteins in the central nervous system. Human genetic studies have established a causal role for protein assembly in neurodegeneration....
2.
Arseni D, Nonaka T, Jacobsen M, Murzin A, Cracco L, Peak-Chew S, et al.
bioRxiv
. 2024 Jul;
PMID: 38979278
Neurodegenerative diseases are characterised by the abnormal filamentous assembly of specific proteins in the central nervous system . Human genetic studies established a causal role for protein assembly in neurodegeneration...
3.
Cracco L, Cali I, Cohen M, Aslam R, Notari S, Kong Q, et al.
Brain
. 2023 Nov;
147(4):1539-1552.
PMID: 38000783
It is increasingly evident that the association of glycans with the prion protein (PrP), a major post-translational modification, significantly impacts the pathogenesis of prion diseases. A recent bioassay study has...
4.
Fontana E, Bongianni M, Benussi A, Bronzato E, Scialo C, Sacchetto L, et al.
Alzheimers Dement
. 2023 Nov;
20(2):1156-1165.
PMID: 37908186
Introduction: We assessed TAR DNA-binding protein 43 (TDP-43) seeding activity and aggregates detection in olfactory mucosa of patients with frontotemporal lobar degeneration with TDP-43-immunoreactive pathology (FTLD-TDP) by TDP-43 seeding amplification...
5.
Cracco L, Puoti G, Cornacchia A, Glisic K, Lee S, Wang Z, et al.
Acta Neuropathol Commun
. 2023 Aug;
11(1):141.
PMID: 37653534
The MV1 and MV2 subtypes of sporadic Creutzfeldt-Jakob disease (sCJD) are linked to the heterozygous methionine (M)/valine (V) polymorphism at codon 129 of the prion protein (PrP) gene. MV2 is...
6.
Cracco L, Doud E, Hallinan G, Garringer H, Jacobsen M, Richardson R, et al.
Neuropathol Appl Neurobiol
. 2022 Jul;
48(6):e12836.
PMID: 35836354
Aims: Frontotemporal dementias are neuropathologically characterised by frontotemporal lobar degeneration (FTLD). Intraneuronal inclusions of transactive response DNA-binding protein 43 kDa (TDP-43) are the defining pathological hallmark of approximately half of...
7.
Hallinan G, Ozcan K, Hoq M, Cracco L, Vago F, Bharath S, et al.
Acta Neuropathol
. 2022 Jul;
144(3):509-520.
PMID: 35819518
Prion protein (PrP) aggregation and formation of PrP amyloid (APrP) are central events in the pathogenesis of prion diseases. In the dominantly inherited prion protein amyloidosis known as Gerstmann-Sträussler-Scheinker (GSS)...
8.
Brennecke N, Cali I, Mok T, Speedy H, Consortium G, Hosszu L, et al.
Viruses
. 2021 Sep;
13(9).
PMID: 34578375
Genetic prion disease accounts for 10-15% of prion disease. While insertion of four or more octapeptide repeats are clearly pathogenic, smaller repeat insertions have an unclear pathogenicity. The goal of...
9.
Cali I, Cracco L, Saracino D, Occhipinti R, Coppola C, Appleby B, et al.
Front Cell Neurosci
. 2020 Aug;
14:150.
PMID: 32733203
The insertion of additional 168 base pair containing seven octapeptide repeats in the prion protein (PrP) gene region spanning residues 51-91 is associated with inherited prion disease. In 2008, we...
10.
Nemani S, Xiao X, Cali I, Cracco L, Puoti G, Nigro M, et al.
Acta Neuropathol Commun
. 2020 Jun;
8(1):85.
PMID: 32560672
One of remarkable features of sporadic Creutzfeldt-Jakob disease (sCJD) is the great phenotypic variability. Understanding the molecular basis of this variability has important implications for the development of therapeutic approaches....