Laura C OBrien
Overview
Explore the profile of Laura C OBrien including associated specialties, affiliations and a list of published articles.
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13
Citations
347
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Recent Articles
1.
OBrien L, Graham Z, Chen Q, Lesnefsky E, Cardozo C, Gorgey A
Spinal Cord
. 2018 Mar;
56(9):863-872.
PMID: 29559683
Study Design: Cross-sectional design. Objectives: This study examined the relationships between circulating adiponectin levels, body composition, metabolic profile, and measures of skeletal muscle mitochondrial enzyme activity and biogenesis. Settings: Clinical...
2.
Rankin K, OBrien L, Gorgey A
J Spinal Cord Med
. 2018 Feb;
42(4):508-516.
PMID: 29461936
Objective: To determine whether dual energy x-ray absorptiometry (DXA) compared to magnetic resonance imaging (MRI) may accurately quantify trunk lean mass (LM) after chronic spinal cord injury (SCI) and to...
3.
Rankin K, OBrien L, Segal L, Khan M, Gorgey A
Biomed Res Int
. 2017 Sep;
2017:1364818.
PMID: 28948164
Purpose: To quantify liver adiposity using magnetic resonance imaging (MRI) and to determine its association with metabolic profile in men with spinal cord injury (SCI). Materials And Methods: MRI analysis...
4.
OBrien L, Chen Q, Savas J, Lesnefsky E, Gorgey A
Eur J Appl Physiol
. 2017 Sep;
117(11):2137-2147.
PMID: 28864949
Purpose: Changes in metabolism and body composition after spinal cord injury (SCI) predispose individuals to obesity, type II diabetes, and cardiovascular disease. A link between lean mass and skeletal muscle...
5.
Gorgey A, Khalil R, Gill R, OBrien L, Lavis T, Castillo T, et al.
BMJ Open
. 2017 Apr;
7(4):e014125.
PMID: 28377392
Introduction: Individuals with spinal cord injury (SCI) are at a lifelong risk of obesity and chronic metabolic disorders including insulin resistance and dyslipidemia. Within a few weeks of injury, there...
6.
OBrien L, Wade R, Segal L, Chen Q, Savas J, Lesnefsky E, et al.
Physiol Rep
. 2017 Feb;
5(3).
PMID: 28193782
Spinal cord injury (SCI) is accompanied by deterioration in body composition and severe muscle atrophy. These changes put individuals at risk for insulin resistance, type II diabetes, and cardiovascular disease....
7.
OBrien L, Gorgey A
World J Orthop
. 2016 Nov;
7(10):628-637.
PMID: 27795944
Mitochondria are the main source of cellular energy production and are dynamic organelles that undergo biogenesis, remodeling, and degradation. Mitochondrial dysfunction is observed in a number of disease states including...
8.
Bennett Jr J, OBrien L, Brohawn D
Biochem Pharmacol
. 2016 Aug;
117:68-77.
PMID: 27498123
Microneurotrophins (MNT's) are small molecule derivatives of dehydroepiandrosterone (DHEA) and do not have significant interactions with sex steroid receptors. MNT's retain high-affinity binding to protein tyrosine kinase (Trk) receptors and...
9.
Brohawn D, OBrien L, Bennett Jr J
PLoS One
. 2016 Aug;
11(8):e0160520.
PMID: 27487029
ALS is a rapidly progressive, devastating neurodegenerative illness of adults that produces disabling weakness and spasticity arising from death of lower and upper motor neurons. No meaningful therapies exist to...
10.
OBrien L, Keeney P, Bennett Jr J
Stem Cells Dev
. 2015 Apr;
24(17):1984-94.
PMID: 25892363
Differentiation of human pluripotent stem cells (hPSCs) in vitro offers a way to study cell types that are not accessible in living patients. Previous research suggests that hPSCs generate ATP...