Laszlo G Harsing Jr
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Explore the profile of Laszlo G Harsing Jr including associated specialties, affiliations and a list of published articles.
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34
Citations
305
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Recent Articles
1.
Harsing Jr L, Szenasi G, Feher B, Miklya I
Neurochem Res
. 2025 Feb;
50(2):94.
PMID: 39903411
Although it is well documented that the striatal GABAergic projection neurons receive excitatory and inhibitory dopaminergic innervation via D1 and D2 receptors, the trace amine-associated receptor 1 (TAAR1)-mediated regulation of...
2.
Papp Z, Ribiczey P, Kato E, Toth Z, Varga Z, Giricz Z, et al.
Biomedicines
. 2025 Jan;
13(1).
PMID: 39857655
Background: N-methyl-D-aspartate type glutamate receptors (NMDARs) are fundamental to neuronal physiology and pathophysiology. The prefrontal cortex (PFC), a key region for cognitive function, is heavily implicated in neuropsychiatric disorders, positioning...
3.
Hanuska A, Ribiczey P, Kato E, Papp Z, Varga Z, Giricz Z, et al.
Int J Mol Sci
. 2024 Dec;
25(23).
PMID: 39684355
NMDA receptors in the prefrontal cortex (PFC) play a crucial role in cognitive functions. Previous research has indicated that angiotensin II (Ang II) affects learning and memory. This study aimed...
4.
Galambos A, Essmat N, Lakatos P, Szucs E, Boldizsar Jr I, Abbood S, et al.
Int J Mol Sci
. 2024 Oct;
25(20).
PMID: 39456918
Opioid analgesic tolerance (OAT), among other central side effects, limits opioids' indispensable clinical use for managing chronic pain. Therefore, there is an existing unmet medical need to prevent OAT. Extrasynaptic...
5.
Galambos A, Papp Z, Boldizsar I, Zador F, Koles L, Harsing Jr L, et al.
Biomedicines
. 2024 Feb;
12(2).
PMID: 38398023
The development of opioid tolerance in patients on long-term opioid analgesic treatment is an unsolved matter in clinical practice thus far. Dose escalation is required to restore analgesic efficacy, but...
6.
Striking Neurochemical and Behavioral Differences in the Mode of Action of Selegiline and Rasagiline
Harsing Jr L, Timar J, Miklya I
Int J Mol Sci
. 2023 Sep;
24(17).
PMID: 37686140
Selegiline and rasagiline are two selective monoamine oxidase B (MAO-B) inhibitors used in the treatment of Parkinson's disease. In their clinical application, however, differences in L-dopa-sparing potencies have been observed....
7.
Spedding M, Sebban C, Jay T, Rocher C, Tesolin-Decros B, Chazot P, et al.
Cells
. 2022 Apr;
11(7).
PMID: 35406745
Dysfunction in the hippocampus-prefrontal cortex (H-PFC) circuit is a critical determinant of schizophrenia. Screening of pyridazinone-risperidone hybrids on this circuit revealed EGIS 11150 (S 36549). EGIS 11150 induced theta rhythm...
8.
Harsing Jr L, Szenasi G, Zelles T, Koles L
Int J Mol Sci
. 2021 Jul;
22(12).
PMID: 34201404
Neurodegenerative-neuroinflammatory disorders of the retina seriously hamper human vision. In searching for key factors that contribute to the development of these pathologies, we considered potential interactions among purinergic neuromodulation, glycinergic...
9.
Mohammadzadeh A, Lakatos P, Balogh M, Zador F, Karadi D, Zadori Z, et al.
Int J Mol Sci
. 2021 Apr;
22(5).
PMID: 33804568
The limited effect of current medications on neuropathic pain (NP) has initiated large efforts to develop effective treatments. Animal studies showed that glycine transporter (GlyT) inhibitors are promising analgesics in...
10.
Al-Khrasani M, Mohammadzadeh A, Balogh M, Kiraly K, Barsi S, Hajnal B, et al.
Brain Res Bull
. 2019 Jul;
152:143-158.
PMID: 31302238
Interneurons operating with glycine neurotransmitter are involved in the regulation of pain transmission in the dorsal horn of the spinal cord. In addition to interneurons, glycine release also occurs from...