Lars Verschuren
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Explore the profile of Lars Verschuren including associated specialties, affiliations and a list of published articles.
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1677
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Recent Articles
1.
de Jong J, Caspers M, Dulos R, Snabel J, van der Hoek M, van der Leij F, et al.
Geroscience
. 2024 Dec;
PMID: 39627572
Frailty is characterized by loss of physical function and is preferably diagnosed at an early stage (e.g., during pre-frailty). Unfortunately, sensitive tools that can aid early detection are lacking. Blood-based...
2.
Custers E, van der Burgh Y, Vreeken D, Schuren F, van den Broek T, Verschuren L, et al.
Heliyon
. 2024 Nov;
10(21):e39899.
PMID: 39559236
Unexplainable gastrointestinal complaints occasionally occur after Roux-en-Y Gastric Bypass (RYGB) surgery. We therefor investigated the impact of microbiota composition and metabolites on gastrointestinal complaints after RYGB. In the BARICO study...
3.
Inia J, Attema J, de Ruiter C, Menke A, Caspers M, Verschuren L, et al.
FASEB J
. 2024 Oct;
38(20):e70087.
PMID: 39463193
Fibroblast growth factor 21 (FGF21) is a promising target for treatment of obesity-associated diseases including metabolic dysfunction-associated steatohepatitis (MASH) and atherosclerosis. We evaluated the effects of the bispecific anti-FGF21-β klotho...
4.
Venhorst J, Hanemaaijer R, Dulos R, Caspers M, Toet K, Attema J, et al.
Front Pharmacol
. 2024 Oct;
15:1442752.
PMID: 39399467
An target discovery pipeline was developed by including a directional and weighted molecular disease network for metabolic dysfunction-associated steatohepatitis (MASH)-induced liver fibrosis. This approach integrates text mining, network biology, and...
5.
Seidel F, Vreeken D, Custers E, Wiesmann M, Ozsezen S, van Duyvenvoorde W, et al.
Heliyon
. 2024 Oct;
10(19):e38516.
PMID: 39391513
It is unclear whether early metabolic and inflammatory aberrations in the liver are associated with detrimental changes in brain structure and cognitive function. This cross-sectional study examines putative associations between...
6.
Gonzalez Hernandez M, Verschuren L, Caspers M, Morrison M, Venhorst J, van den Berg J, et al.
Sci Rep
. 2024 Oct;
14(1):23362.
PMID: 39375498
The incidence of MASLD and MASH-associated fibrosis is rapidly increasing worldwide. Drug therapy is hampered by large patient variability and partial representation of human MASH fibrosis in preclinical models. Here,...
7.
Martens N, Zhan N, Yam S, Leijten F, Palumbo M, Caspers M, et al.
Nutrients
. 2024 Jun;
16(11).
PMID: 38892548
We previously demonstrated that diet supplementation with seaweed () prevented AD-related pathology in a mouse model of Alzheimer's Disease (AD). Here, we tested a lipid extract of seaweed () and...
8.
Verschuren L, Mak A, van Koppen A, Ozsezen S, Difrancesco S, Caspers M, et al.
Nat Commun
. 2024 May;
15(1):4564.
PMID: 38811591
Accurate non-invasive biomarkers to diagnose metabolic dysfunction-associated steatotic liver disease (MASLD)-related fibrosis are urgently needed. This study applies a translational approach to develop a blood-based biomarker panel for fibrosis detection...
9.
Hogenelst K, Ozsezen S, Kleemann R, Verschuren L, Stuldreher I, Bottenheft C, et al.
Brain Behav Immun Health
. 2024 May;
38:100789.
PMID: 38799794
With the purpose of identifying a sensitive, robust, and easy-to-measure set of biomarkers to assess stress reactivity, we here study a large set of relatively easy to obtain markers reflecting...
10.
de Jong J, Caspers M, Worms N, Keijzer N, Kleemann R, Menke A, et al.
Geroscience
. 2024 Jan;
46(3):3341-3360.
PMID: 38265577
Muscle-aging drives sarcopenia and is a major public health issue. Mice are frequently used as a model for human muscle-aging, however, research investigating their translational value is limited. In addition,...