Lars L P Hanssen
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Explore the profile of Lars L P Hanssen including associated specialties, affiliations and a list of published articles.
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9
Citations
807
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Recent Articles
1.
King A, Songdej D, Downes D, Beagrie R, Liu S, Buckley M, et al.
Nat Commun
. 2021 Jul;
12(1):4439.
PMID: 34290235
The α- and β-globin loci harbor developmentally expressed genes, which are silenced throughout post-natal life. Reactivation of these genes may offer therapeutic approaches for the hemoglobinopathies, the most common single...
2.
Hua P, Badat M, Hanssen L, Hentges L, Crump N, Downes D, et al.
Nature
. 2021 Jun;
595(7865):125-129.
PMID: 34108683
In higher eukaryotes, many genes are regulated by enhancers that are 10-10 base pairs (bp) away from the promoter. Enhancers contain transcription-factor-binding sites (which are typically around 7-22 bp), and...
3.
Oudelaar A, Harrold C, Hanssen L, Telenius J, Higgs D, Hughes J
Nat Commun
. 2019 Nov;
10(1):5412.
PMID: 31776347
Specific communication between gene promoters and enhancers is critical for accurate regulation of gene expression. However, it remains unclear how specific interactions between multiple regulatory elements contained within a single...
4.
Oudelaar A, Davies J, Hanssen L, Telenius J, Schwessinger R, Liu Y, et al.
Nat Genet
. 2018 Oct;
50(12):1744-1751.
PMID: 30374068
The promoters of mammalian genes are commonly regulated by multiple distal enhancers, which physically interact within discrete chromatin domains. How such domains form and how the regulatory elements within them...
5.
Oudelaar A, Hanssen L, Hardison R, Kassouf M, Hughes J, Higgs D
Hum Mol Genet
. 2017 Oct;
26(R2):R208-R215.
PMID: 28977451
It has been known for over a century that chromatin is not randomly distributed within the nucleus. However, the question of how DNA is folded and the influence of such...
6.
Hanssen L, Kassouf M, Oudelaar A, Biggs D, Preece C, Downes D, et al.
Nat Cell Biol
. 2017 Jul;
19(8):952-961.
PMID: 28737770
The genome is organized via CTCF-cohesin-binding sites, which partition chromosomes into 1-5 megabase (Mb) topologically associated domains (TADs), and further into smaller sub-domains (sub-TADs). Here we examined in vivo an...
7.
Blackledge N, Farcas A, Kondo T, King H, McGouran J, Hanssen L, et al.
Cell
. 2014 May;
157(6):1445-1459.
PMID: 24856970
Chromatin modifying activities inherent to polycomb repressive complexes PRC1 and PRC2 play an essential role in gene regulation, cellular differentiation, and development. However, the mechanisms by which these complexes recognize...
8.
van Heeringen S, Akkers R, van Kruijsbergen I, Arif M, Hanssen L, Sharifi N, et al.
Genome Res
. 2013 Dec;
24(3):401-10.
PMID: 24336765
During embryonic development, maintenance of cell identity and lineage commitment requires the Polycomb-group PRC2 complex, which catalyzes histone H3 lysine 27 trimethylation (H3K27me3). However, the developmental origins of this regulation...
9.
Heldens L, van Genesen S, Hanssen L, Hageman J, Kampinga H, Lubsen N
Cell Stress Chaperones
. 2012 Apr;
17(5):603-13.
PMID: 22477622
Post-heat shock refolding of luciferase requires chaperones. Expression of a dominant negative HSF1 mutant (dnHSF1), which among other effects depletes cells of HSF1-regulated chaperones, blocked post-heat shock refolding of luciferase...