Lars Christophersen
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Explore the profile of Lars Christophersen including associated specialties, affiliations and a list of published articles.
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28
Citations
553
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Recent Articles
21.
Thomsen K, Christophersen L, Jensen P, Bjarnsholt T, Moser C, Hoiby N
Hum Vaccin Immunother
. 2016 Feb;
12(7):1690-9.
PMID: 26901841
Moderation of polymorphonuclear neutrophils (PMNs) as part of a critical defense against invading pathogens may offer a promising therapeutic approach to supplement the antibiotic eradication of Pseudomonas aeruginosa infection in...
22.
Cao B, Christophersen L, Thomsen K, Sonderholm M, Bjarnsholt T, Jensen P, et al.
J Antimicrob Chemother
. 2015 Mar;
70(7):2057-63.
PMID: 25786481
Objectives: Treating biofilm infections successfully is a challenge. We hypothesized that biofilms may be considered as independent compartments with particular pharmacokinetics. We therefore studied the pharmacokinetics and pharmacodynamics of tobramycin...
23.
Cavanagh J, Granslo H, Fredheim E, Christophersen L, Jensen P, Thomsen K, et al.
J Antimicrob Chemother
. 2013 May;
68(9):2106-10.
PMID: 23645587
Objectives: Biofilm-forming Staphylococcus epidermidis is a prevalent cause of peritonitis during peritoneal dialysis. We compared the efficacy of a synthetic antimicrobial peptidomimetic (Ltx21) versus vancomycin in a murine model mimicking...
24.
van Gennip M, Moser C, Christensen L, Bjarnsholt T, Calum H, Jensen P, et al.
J Antimicrob Chemother
. 2009 Oct;
64(6):1241-50.
PMID: 19815632
Background: Effects of treatment with tobramycin initiated 1 or 24 h post-infection were investigated in a new version of a pulmonary infection model in mice. The model reflects the differentiated...
25.
Alhede M, Bjarnsholt T, Jensen P, Phipps R, Moser C, Christophersen L, et al.
Microbiology (Reading)
. 2009 Aug;
155(Pt 11):3500-3508.
PMID: 19643762
Polymorphonuclear neutrophilic leukocytes (PMNs) play a central role in innate immunity, where they dominate the response to infections, in particular in the cystic fibrosis lung. PMNs are phagocytic cells that...
26.
van Gennip M, Christensen L, Alhede M, Phipps R, Jensen P, Christophersen L, et al.
APMIS
. 2009 Jul;
117(7):537-46.
PMID: 19594494
Many of the virulence factors produced by the opportunistic human pathogen Pseudomonas aeruginosa are quorum-sensing (QS) regulated. Among these are rhamnolipids, which have been shown to cause lysis of several...
27.
Christensen L, Moser C, Jensen P, Rasmussen T, Christophersen L, Kjelleberg S, et al.
Microbiology (Reading)
. 2007 Jun;
153(Pt 7):2312-2320.
PMID: 17600075
Pseudomonas aeruginosa is an opportunistic human pathogen that causes chronic biofilm-based infections in host organisms. P. aeruginosa employs quorum sensing (QS) to control expression of its virulence, and to establish...
28.
Bjarnsholt T, Jensen P, Rasmussen T, Christophersen L, Calum H, Hentzer M, et al.
Microbiology (Reading)
. 2005 Dec;
151(Pt 12):3873-3880.
PMID: 16339933
The opportunistic human pathogen Pseudomonas aeruginosa is the predominant micro-organism of chronic lung infections in cystic fibrosis patients. P. aeruginosa colonizes the lungs by forming biofilm microcolonies throughout the lung....