Larisa V Kovtonyuk
Overview
Explore the profile of Larisa V Kovtonyuk including associated specialties, affiliations and a list of published articles.
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16
Citations
1080
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Recent Articles
1.
Lysenko V, Schurch P, Tuzlak S, van Wijk N, Kovtonyuk L, Becher B, et al.
Leukemia
. 2023 Apr;
37(6):1277-1286.
PMID: 37095207
Polycythemia vera (PV) is a hematopoietic stem cell neoplasm driven by somatic mutations in JAK2, leading to increased red blood cell (RBC) production uncoupled from mechanisms that regulate physiological erythropoiesis....
2.
Kovtonyuk L, McCoy K
Semin Immunol
. 2023 Mar;
67:101755.
PMID: 36989542
Our microbiota has a critical role in shaping host immunity. Microbes that reside in the gut harbor a large metabolic arsenal to aid in physiological functions of the host. Microbial...
3.
Caiado F, Kovtonyuk L, Gonullu N, Fullin J, Boettcher S, Manz M
Blood
. 2022 Nov;
141(8):886-903.
PMID: 36379023
Clonal hematopoiesis of indeterminate potential (CHIP), also referred to as aging-related clonal hematopoiesis, is defined as an asymptomatic clonal expansion of mutant mature hematopoietic cells in ≥4% of blood leukocytes....
4.
Wilk C, Kovtonyuk L, Manz M
Blood Adv
. 2022 Jun;
6(15):4485-4489.
PMID: 35736667
Allogeneic hematopoietic stem cell transplantation (HSCT) offers a curative treatment approach for certain benign and malignant hematologic diseases. The actual HSCT is preceded by a conditioning therapy that reduces host-vs-HSCT...
5.
TP53 mutations confer resistance to hypomethylating agents and BCL-2 inhibition in myeloid neoplasms
Schimmer R, Kovtonyuk L, Klemm N, Fullin J, Stolz S, Mueller J, et al.
Blood Adv
. 2022 Jan;
6(11):3201-3206.
PMID: 35026842
No abstract available.
6.
Gerosa R, Boettcher S, Kovtonyuk L, Hausmann A, Hardt W, Hidalgo J, et al.
Blood Adv
. 2021 Sep;
5(23):5002-5015.
PMID: 34581809
Hematopoiesis is maintained by hematopoietic stem and progenitor cells that are located in the bone marrow (BM) where they are embedded within a complex supportive microenvironment consisting of a multitude...
7.
Kovtonyuk L, Caiado F, Garcia-Martin S, Manz E, Helbling P, Takizawa H, et al.
Blood
. 2021 Sep;
139(1):44-58.
PMID: 34525198
Aging is associated with impaired hematopoietic and immune function caused in part by decreased fitness in the hematopoietic stem cell (HSC) population and an increased myeloid differentiation bias. The reasons...
8.
Giger S, Kovtonyuk L, Utz S, Ramosaj M, Kovacs W, Schmid E, et al.
Stem Cell Reports
. 2020 Aug;
15(3):566-576.
PMID: 32857979
Fatty acid β-oxidation (FAO), the breakdown of lipids, is a metabolic pathway used by various stem cells. FAO levels are generally high during quiescence and downregulated with proliferation. The endogenous...
9.
Takizawa H, Fritsch K, Kovtonyuk L, Saito Y, Yakkala C, Jacobs K, et al.
Cell Stem Cell
. 2020 Jul;
27(1):177.
PMID: 32619512
No abstract available.
10.
Takizawa H, Fritsch K, Kovtonyuk L, Saito Y, Yakkala C, Jacobs K, et al.
Cell Stem Cell
. 2017 Jul;
21(2):225-240.e5.
PMID: 28736216
Bacterial infection leads to consumption of short-lived innate immune effector cells, which then need to be replenished from hematopoietic stem and progenitor cells (HSPCs). HSPCs express pattern recognition receptors, such...