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Lara Senn

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Articles 5
Citations 49
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Recent Articles
1.
Senn L, Costa A, Avallone R, Socala K, Wlaz P, Biagini G
Pharmacol Ther . 2022 Nov; 241:108316. PMID: 36436690
The peroxisome proliferator-activated receptor gamma (PPARγ), which belongs to the family of nuclear receptors, has been mainly studied as an important factor in metabolic disorders. However, in recent years the...
2.
Costa A, Russo F, Senn L, Ibatici D, Cannazza G, Biagini G
Pharmaceuticals (Basel) . 2022 May; 15(5). PMID: 35631322
We evaluated the effects of cannabidiol (CBD) on seizures and peroxisome proliferator-activated receptor gamma (PPARγ) levels in an animal model of temporal lobe epilepsy (TLE). Adult male Sprague-Dawley rats were...
3.
Costa A, Senn L, Anceschi L, Brighenti V, Pellati F, Biagini G
Pharmaceuticals (Basel) . 2021 Dec; 14(12). PMID: 34959660
Compounds present in L. preparations have recently attracted much attention in the treatment of drug-resistant epilepsy. Here, we screened two olive oil extracts from a non-psychoactive variety, fully characterized by...
4.
Lucchi C, Costa A, Senn L, Messina S, Rustichelli C, Biagini G
Epilepsia . 2020 Sep; 61(9):e129-e134. PMID: 32929741
Neurosteroids can modulate γ-aminobutyric acid type A receptor-mediated inhibitory currents. Recently, we discovered that the neurosteroids progesterone, 5α-dihydroprogesterone, allopregnanolone, and pregnanolone are reduced in the cerebrospinal fluid of patients with...
5.
Senn L, Cannazza G, Biagini G
Pharmaceuticals (Basel) . 2020 Aug; 13(8). PMID: 32751761
Epilepsy contributes to approximately 1% of the global disease burden. By affecting especially young children as well as older persons of all social and racial variety, epilepsy is a present...