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Lara Baldwin

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Citations 86
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Recent Articles
1.
Chopra S, Levi P, Holmes A, Orchard E, Segal A, Francey S, et al.
Biol Psychiatry . 2024 Jul; 97(2):157-166. PMID: 39069164
Background: Disruptions of axonal connectivity are thought to be a core pathophysiological feature of psychotic illness, but whether they are present early in the illness, prior to antipsychotic exposure, and...
2.
Chopra S, Segal A, Oldham S, Holmes A, Sabaroedin K, Orchard E, et al.
JAMA Psychiatry . 2023 Sep; 80(12):1246-1257. PMID: 37728918
Importance: Psychotic illness is associated with anatomically distributed gray matter reductions that can worsen with illness progression, but the mechanisms underlying the specific spatial patterning of these changes is unknown....
3.
Allott K, Yuen H, Baldwin L, ODonoghue B, Fornito A, Chopra S, et al.
Transl Psychiatry . 2023 Jun; 13(1):199. PMID: 37301832
The drivers of cognitive change following first-episode psychosis remain poorly understood. Evidence regarding the role of antipsychotic medication is primarily based on naturalistic studies or clinical trials without a placebo...
4.
Oldehinkel M, Tiego J, Sabaroedin K, Chopra S, Francey S, ODonoghue B, et al.
Transl Psychiatry . 2023 Apr; 13(1):128. PMID: 37072388
Both psychotic illness and subclinical psychosis-like experiences (PLEs) have been associated with cortico-striatal dysfunction. This work has largely relied on a discrete parcellation of the striatum into distinct functional areas,...
5.
ODonoghue B, Allott K, Harrigan S, Scalzo F, Ward J, Mallawaarachchi S, et al.
Early Interv Psychiatry . 2022 Oct; 17(6):597-607. PMID: 36196478
Background: Cardiovascular and metabolic diseases are the leading contributors to the early mortality associated with psychotic disorders. To date, it has not been possible to disentangle the effect of medication...
6.
Chopra S, Francey S, ODonoghue B, Sabaroedin K, Arnatkeviciute A, Cropley V, et al.
JAMA Psychiatry . 2021 Jun; 78(9):994-1004. PMID: 34160595
Importance: Altered functional connectivity (FC) is a common finding in resting-state functional magnetic resonance imaging (rs-fMRI) studies of people with psychosis, yet how FC disturbances evolve in the early stages...
7.
Whitson S, ODonoghue B, Hester R, Baldwin L, Harrigan S, Francey S, et al.
Schizophr Res Cogn . 2021 Mar; 24:100194. PMID: 33659191
Cognitive impairments are a core feature of first-episode psychosis (FEP), arising before illness onset and antipsychotic exposure. Individuals with chronic psychosis experience poorer physical health while taking antipsychotic medication, but...
8.
Chopra S, Fornito A, Francey S, ODonoghue B, Cropley V, Nelson B, et al.
Neuropsychopharmacology . 2021 Feb; 46(8):1494-1501. PMID: 33637835
Changes in brain volume are a common finding in Magnetic Resonance Imaging (MRI) studies of people with psychosis and numerous longitudinal studies suggest that volume deficits progress with illness duration....
9.
ODonoghue B, Francey S, Nelson B, Ratheesh A, Allott K, Graham J, et al.
Early Interv Psychiatry . 2018 Jul; 13(4):953-960. PMID: 30024100
Aim: It is now necessary to investigate whether recovery in psychosis is possible without the use of antipsychotic medication. This study will determine (1) whether a first-episode psychosis (FEP) group...
10.
Allott K, Yuen H, Bartholomeusz C, Rapado-Castro M, Phassouliotis C, Butselaar F, et al.
Psychiatry Res . 2017 Nov; 260:60-66. PMID: 29175500
Aims: Memory impairment in psychosis may be mediated through detrimental effects of hypothalamic-pituitary-adrenal (HPA) axis function. This study prospectively investigated the relationship between cortisol, sulphate dehydroepiandrosterone (DHEA(S) and cortisol: DHEA(S)...