Lap Man Lee
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Explore the profile of Lap Man Lee including associated specialties, affiliations and a list of published articles.
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20
Citations
404
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Recent Articles
1.
Lee L, Bhatt K, Haithcock D, Prabhakarpandian B
Biomicrofluidics
. 2023 Oct;
17(5):054106.
PMID: 37854890
Separation of blood components is required in many diagnostic applications and blood processes. In laboratories, blood is usually fractionated by manual operation involving a bulk centrifugation equipment, which significantly increases...
2.
Lee L, Klarmann G, Haithcock D, Wang Y, Bhatt K, Prabhakarpandian B, et al.
Lab Chip
. 2023 Mar;
23(8):2131-2140.
PMID: 36974599
Human adipose tissue is a rich source of mesenchymal stem cells (MSCs). Human adipose-derived stem cells (ADSCs) are first prepared by tissue digestion of lipoaspirate. The remaining constituent contains a...
3.
Helms A, Tang V, OLeary T, Friedline S, Wauchope M, Arora A, et al.
JCI Insight
. 2019 Dec;
5(2).
PMID: 31877118
Mutations in cardiac myosin binding protein C (MyBP-C, encoded by MYBPC3) are the most common cause of hypertrophic cardiomyopathy (HCM). Most MYBPC3 mutations result in premature termination codons (PTCs) that...
4.
Heureaux-Torres J, Luker K, Haley H, Pirone M, Lee L, Herrera Y, et al.
APL Bioeng
. 2019 May;
2(3):032001.
PMID: 31069318
Metastatic cancer cells migrate through constricted spaces and experience significant compressive stress, but mechanisms enabling migration in confined geometries remain unclear. Cancer cell migration within confined 3-dimensional (3D) microfluidic channels...
5.
Glazier A, Hafeez N, Mellacheruvu D, Basrur V, Nesvizhskii A, Lee L, et al.
JCI Insight
. 2018 Jun;
3(11).
PMID: 29875314
Cardiac myosin binding protein C (MYBPC3) is the most commonly mutated gene associated with hypertrophic cardiomyopathy (HCM). Haploinsufficiency of full-length MYBPC3 and disruption of proteostasis have both been proposed as...
6.
Ma F, Chung M, Yao Y, Nidetz R, Lee L, Liu A, et al.
Nat Commun
. 2018 Mar;
9(1):1030.
PMID: 29531246
Directed evolution has long been a key strategy to generate enzymes with desired properties like high selectivity, but experimental barriers and analytical costs of screening enormous mutant libraries have limited...
7.
Lee L, Lee J, Chase D, Gebrezgiabhier D, Liu A
Biomicrofluidics
. 2016 Oct;
10(5):054105.
PMID: 27703591
Various micro-engineered tools or platforms have been developed recently for cell mechanics studies based on acoustic, magnetic, and optical actuations. Compared with other techniques for single cell manipulations, microfluidics has...
8.
Ho K, Lee L, Liu A
Sci Rep
. 2016 Sep;
6:32912.
PMID: 27610921
All living organisms sense mechanical forces. Engineering mechanosensitive artificial cell through bottom-up in vitro reconstitution offers a way to understand how mixtures of macromolecules assemble and organize into a complex...
9.
Lee L, Liu A
J Nanotechnol Eng Med
. 2015 Jul;
5(4):0408011-408016.
PMID: 26155329
Micropipette aspiration is arguably the most classical technique in mechanical measurements and manipulations of single cells. Despite its simplicity, micropipette aspiration has been applied to a variety of experimental systems...
10.
Lee L, Liu A
Lab Chip
. 2014 Nov;
15(1):264-73.
PMID: 25361042
Micropipette aspiration measures the mechanical properties of single cells. A traditional micropipette aspiration system requires a bulky infrastructure and has a low throughput and limited potential for automation. We have...