Lance R Pohl
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Explore the profile of Lance R Pohl including associated specialties, affiliations and a list of published articles.
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24
Citations
754
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Recent Articles
1.
Northrup D, Yagi R, Cui K, Proctor W, Wang C, Placek K, et al.
Cell Biosci
. 2017 May;
7:25.
PMID: 28529687
Background: Natural killer (NK)T cells and conventional T cells share phenotypic characteristic however they differ in transcription factor requirements and functional properties. The role of histone modifying enzymes in conventional...
2.
Chakraborty M, Fullerton A, Semple K, Chea L, Proctor W, Bourdi M, et al.
Hepatology
. 2015 Feb;
62(2):546-57.
PMID: 25712247
Unlabelled: Clinical evidence suggests that many cases of serious idiosyncratic drug-induced liver injury are mediated by the adaptive immune system in response to hepatic drug-protein adducts, also referred to as...
3.
Proctor W, Chakraborty M, Fullerton A, Korrapati M, Ryan P, Semple K, et al.
Hepatology
. 2014 Apr;
60(5):1741-52.
PMID: 24723460
Unlabelled: Liver eosinophilia has been associated with incidences of drug-induced liver injury (DILI) for more than 50 years, although its role in this disease has remained largely unknown. In this...
4.
Proctor W, Chakraborty M, Chea L, Morrison J, Berkson J, Semple K, et al.
Hepatology
. 2012 Dec;
57(5):2026-36.
PMID: 23238640
Unlabelled: Drug-induced liver injury (DILI) is a major health issue, as it remains difficult to predict which new drugs will cause injury and who will be susceptible to this disease....
5.
Ryan P, Bourdi M, Korrapati M, Proctor W, Vasquez R, Yee S, et al.
Chem Res Toxicol
. 2011 Nov;
25(1):83-93.
PMID: 22107450
In a recent study, we reported that interleukin (IL)-4 had a protective role against acetaminophen (APAP)-induced liver injury (AILI), although the mechanism of protection was unclear. Here, we carried out...
6.
Lu Z, Bourdi M, Li J, Aponte A, Chen Y, Lombard D, et al.
EMBO Rep
. 2011 Jul;
12(8):840-6.
PMID: 21720390
Acetaminophen/paracetamol-induced liver failure--which is induced by the binding of reactive metabolites to mitochondrial proteins and their disruption--is exacerbated by fasting. As fasting promotes SIRT3-mediated mitochondrial-protein deacetylation and acetaminophen metabolites bind...
7.
Bourdi M, Davies J, Pohl L
Chem Res Toxicol
. 2011 May;
24(6):794-6.
PMID: 21557537
C57BL/6 mice are widely used in biomedical research for the background of genetically engineered mice (GEM) and wild-type controls with the belief that the genetic background of GEM and control...
8.
Masson M, Collins L, Carpenter L, Graf M, Ryan P, Bourdi M, et al.
Biochem Biophys Res Commun
. 2010 Jun;
397(3):453-8.
PMID: 20510877
Unlabelled: We previously reported that acetaminophen (APAP)-induced liver injury (AILI) in mice is associated with a rise in serum levels of the glucocorticoid (GC), corticosterone. In the current study, we...
9.
Masson M, Collins L, Pohl L
Handb Exp Pharmacol
. 2009 Dec;
(196):195-231.
PMID: 20020264
Cytokines are thought to play a role in acute and/or immune-mediated adverse drug reactions (ADRs) due to their ability to regulate the innate and adaptive immune systems. This role is...
10.
Masson M, Carpenter L, Graf M, Pohl L
Hepatology
. 2008 Aug;
48(3):889-97.
PMID: 18712839
Unlabelled: Dimethyl sulfoxide (DMSO) is commonly used in biological studies to dissolve drugs and enzyme inhibitors with low solubility. Although DMSO is generally thought of as being relatively inert, it...