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Lana McClements

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Articles 55
Citations 814
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Recent Articles
21.
Afrose D, Chen H, Ranashinghe A, Liu C, Henessy A, Hansbro P, et al.
Biol Sex Differ . 2022 Jun; 13(1):26. PMID: 35658944
Background: Preeclampsia is a multifactorial cardiovascular disorder of pregnancy. If left untreated, it can lead to severe maternal and fetal outcomes. Hence, timely diagnosis and management of preeclampsia are extremely...
22.
McClements L, Richards C, Patel N, Chen H, Sesperez K, Bubb K, et al.
Sci Rep . 2022 Jan; 12(1):1111. PMID: 35064159
Preeclampsia is a cardiovascular pregnancy complication characterised by new onset hypertension and organ damage or intrauterine growth restriction. It is one of the leading causes of maternal and fetal mortality...
23.
Chen H, Chhor M, Rayner B, McGrath K, McClements L
Arch Cardiovasc Dis . 2021 Nov; 114(12):793-804. PMID: 34802963
Background: A number of circulating biomarkers are currently utilized for the diagnosis of chronic heart failure with preserved ejection fraction (HFpEF). However, due to HFpEF heterogeneity, the accuracy of these...
24.
Augustine R, S A, Nayeem A, Salam S, Augustine P, Dan P, et al.
Chem Biol Interact . 2021 Nov; 351:109738. PMID: 34740598
The rapid spread of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) that causes coronavirus disease 2019 (COVID-19), has had a dramatic negative impact on public health and economies worldwide. Recent...
25.
McNally R, Alqudah A, McErlean E, Rennie C, Morshed N, Short A, et al.
Nanomedicine (Lond) . 2021 Aug; 16(22):1999-2012. PMID: 34435509
Overexpression of sFlt-1 or modulation of FKBPL, key antiangiogenic proteins, are important in the pathogenesis of preeclampsia. A newly developed nonviral gene-delivery system, RALA, capable of overexpressing sFlt-1 (e15a isoform)...
26.
Alqudah A, Wedyan M, Qnais E, Jawarneh H, McClements L
Front Pharmacol . 2021 Aug; 12:695418. PMID: 34335259
The perturbation in plasma free amino acid metabolome has been observed previously in diabetes mellitus, and is associated with insulin resistance as well as the onset of cardiovascular disease in...
27.
Alqudah A, Eastwood K, Jerotic D, Todd N, Hoch D, McNally R, et al.
Front Endocrinol (Lausanne) . 2021 Jun; 12:650328. PMID: 34149611
Diabetes in pregnancy is associated with adverse pregnancy outcomes including preterm birth. Although the mechanisms leading to these pregnancy complications are still poorly understood, aberrant angiogenesis and endothelial dysfunction play...
28.
Liu Chung Ming C, Sesperez K, Ben-Sefer E, Arpon D, McGrath K, McClements L, et al.
Cells . 2021 Apr; 10(4). PMID: 33919808
Preeclampsia is a multifactorial cardiovascular disorder diagnosed after 20 weeks of gestation, and is the leading cause of death for both mothers and babies in pregnancy. The pathophysiology remains poorly...
29.
Richards C, Sesperez K, Chhor M, Ghorbanpour S, Rennie C, Liu Chung Ming C, et al.
Biol Sex Differ . 2021 Apr; 12(1):31. PMID: 33879252
Background: Preeclampsia is a dangerous cardiovascular disorder of pregnancy that leads to an increased risk of future cardiovascular and metabolic disorders. Much of the pathogenesis and mechanisms involved in cardiac...
30.
Ryan S, Hosseini-Beheshti E, Afrose D, Ding X, Xia B, Grau G, et al.
Int J Mol Sci . 2021 Apr; 22(6). PMID: 33809632
Over the past two decades, mesenchymal stromal cells (MSCs) have demonstrated great potential in the treatment of inflammation-related conditions. Numerous early stage clinical trials have suggested that this treatment strategy...