Lakshmi Manasa S Chekka
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Explore the profile of Lakshmi Manasa S Chekka including associated specialties, affiliations and a list of published articles.
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6
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17
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Recent Articles
1.
Chekka L, Tantawy M, Langaee T, Wang D, Renne R, Chapman A, et al.
J Am Heart Assoc
. 2024 Feb;
13(4):e032433.
PMID: 38353215
Background: Thiazide diuretics are the second most frequently prescribed class of antihypertensives, but up to 50% of patients with hypertension have minimal antihypertensive response to thiazides. We explored circulating microRNAs...
2.
Hyland P, Chekka L, Samarth D, Rosenzweig B, Decker E, Mohamed E, et al.
Clin Pharmacol Ther
. 2022 Oct;
113(1):98-107.
PMID: 36308070
Proteomics has the potential to identify pharmacodynamic (PD) biomarkers for similarity assessment of proposed biosimilars without relying on clinical efficacy end points. In this study, with 36 healthy participants randomized...
3.
Chekka L, Cooper-DeHoff R, Gums J, Chapman A, Johnson J
Clin Transl Sci
. 2022 Oct;
15(12):2858-2867.
PMID: 36271676
This study conducted a pairwise comparison of antihypertensive and metabolic effects of hydrochlorothiazide (HCTZ) and chlorthalidone (CTD) at 25 mg/day in the same individuals to address the clinical dilemma on...
4.
Armstrong N, Srinivasasainagendra V, Chekka L, Nguyen N, Nahid N, Jones A, et al.
Genes (Basel)
. 2022 Jul;
13(7).
PMID: 35886043
Hypertension is a leading risk factor for cardiovascular disease mortality. African Americans (AAs) have the highest prevalence of hypertension in the United States, and to alleviate the burden of hypertension...
5.
Chekka L, Langaee T, Johnson J
Front Genet
. 2022 Apr;
13:836636.
PMID: 35432462
MicroRNAs are small noncoding RNAs with potential regulatory roles in hypertension and drug response. The presence of many of these RNAs in biofluids has spurred investigation into their role as...
6.
Chekka L, Chapman A, Gums J, Cooper-DeHoff R, Johnson J
Am J Med
. 2021 Jan;
134(7):918-925.e2.
PMID: 33434556
Background: Chlorthalidone is recommended over hydrochlorothiazide (HCTZ) as the preferred thiazide, but the supporting evidence is not robust at routinely used doses, or in whites vs blacks, in whom differences...