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Lakshman Balaji

Explore the profile of Lakshman Balaji including associated specialties, affiliations and a list of published articles. Areas
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Articles 24
Citations 60
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Recent Articles
1.
Vine J, Lee J, Balaji L, Grossestreuer A, Morton A, Peradze N, et al.
Intensive Care Med Exp . 2024 Nov; 12(1):97. PMID: 39497011
Background: Diabetic ketoacidosis (DKA) is a potentially life-threatening disorder associated with severe alterations in metabolism and acid-base status. Mitochondrial dysfunction is associated with diabetes and its complications. Thiamine and coenzyme...
2.
Mangino A, Balaji L, Stenson B, Nathanson L, Chiu D, Grossman S
J Am Coll Emerg Physicians Open . 2024 Aug; 5(4):e13195. PMID: 39104919
Objectives: During the coronavirus disease 2019 (COVID-19) pandemic surge, alternate care sites (ACS) such as the waiting room or hospital lobby were created amongst hospitals nationwide to help alleviate emergency...
3.
Shea M, Balaji L, Grossestreuer A, Issa M, Silverman J, Li F, et al.
Resusc Plus . 2024 Jun; 19:100667. PMID: 38827271
Aim: Whether changes in oxygen metabolism, as measured by oxygen consumption (VO), carbon dioxide production (VCO) and the respiratory exchange ratio (RER), are associated with survival after cardiac arrest is...
4.
Vine J, Berlin N, Moskowitz A, Berg K, Liu X, Balaji L, et al.
Contemp Clin Trials . 2024 Mar; 139:107486. PMID: 38431131
Introduction: Acute pancreatitis is a common disease which, in its severe form, is associated with significant morbidity and mortality. Currently, there is no specific therapy known to attenuate organ failure...
5.
Berg K, Grossestreuer A, Balaji L, Moskowitz A, Berlin N, Cocchi M, et al.
Resuscitation . 2024 Mar; 198:110160. PMID: 38428722
Introduction: Elevated lactate is associated with mortality after cardiac arrest. Thiamine, a cofactor of pyruvate dehydrogenase, is necessary for aerobic metabolism. In a mouse model of cardiac arrest, thiamine improved...
6.
Donnino M, Berg K, Vine J, Balaji L, Berlin N, Cocchi M, et al.
Resuscitation . 2024 Mar; 198:110158. PMID: 38428720
Introduction: Thiamine is a key cofactor for aerobic metabolism, previously shown to improve mortality and neurological outcomes in a mouse model of cardiac arrest. We hypothesized that thiamine would decrease...
7.
Vine J, Mehta S, Balaji L, Berg K, Berlin N, Liu X, et al.
BMJ Open . 2024 Feb; 14(2):e077586. PMID: 38423765
Introduction: Diabetic ketoacidosis (DKA) is a potentially life-threatening diabetic complication. Despite the high prevalence of DKA and the substantial associated healthcare burden, limited research on strategies to improve outcomes currently...
8.
Vine J, Lee J, Kravitz M, Grossestreuer A, Balaji L, Leland S, et al.
Crit Care . 2024 Feb; 28(1):41. PMID: 38321529
Background: This is a post hoc analysis of combined cohorts from two previous Phase II clinical trials to assess the effect of thiamine administration on kidney protection and mortality in...
9.
Berlin N, Pawar R, Liu X, Balaji L, Morton A, Silverman J, et al.
Resuscitation . 2023 Jul; 190:109911. PMID: 37499974
Aim: To evaluate the performance of kidney-specific biomarkers (neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule-1 (KIM-1), and cystatin-C) in early detection of acute kidney injury (AKI) following cardiac arrest (CA)...
10.
Moskowitz A, Berg K, Grossestreuer A, Balaji L, Liu X, Cocchi M, et al.
Am J Respir Crit Care Med . 2023 Jun; 208(5):570-578. PMID: 37364280
Kidney injury is common and associated with worse outcomes in patients with septic shock. Mitochondrial resuscitation with thiamine (vitamin B1) may attenuate septic kidney injury. To assess whether thiamine supplementation...