L R Friedman
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Explore the profile of L R Friedman including associated specialties, affiliations and a list of published articles.
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Articles
24
Citations
183
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Recent Articles
1.
He J, Agarwal M, Larkin H, Friedman L, Xue L, Oleinick N
Photochem Photobiol
. 1996 Nov;
64(5):845-52.
PMID: 8931384
Photodynamic therapy (PDT) is an efficient inducer of apoptosis, an active form of cell death that can be inhibited by the BCL-2 oncoprotein. The ability of BCL-2 to modulate PDT-induced...
2.
Chiu S, Xue L, Friedman L, Oleinick N
Biochemistry
. 1995 Feb;
34(8):2653-61.
PMID: 7873547
The induction of DNA DSB (double-strand breaks) in isolated nuclear chromatin by Cu(II) or Fe(II)-EDTA in the presence of H2O2 and ascorbate has been compared to DSB induction by gamma-radiation....
3.
Xue L, Friedman L, Oleinick N, Chiu S
Int J Radiat Biol
. 1994 Jul;
66(1):11-21.
PMID: 8027606
The influence of chromatin proteins on the induction of DNA double-strand breaks (dsb) and DNA-protein crosslinks (dpc) by gamma-radiation was investigated. Low molecular weight non-histone proteins and classes of histones...
4.
Chiu S, Xue L, Friedman L, Oleinick N
Biochemistry
. 1993 Jun;
32(24):6214-9.
PMID: 8512931
Exposure of mammalian cells to ionizing radiation induces nuclear matrix proteins and their attached transcribing DNA sequences to form cross-links. To characterize the cellular and matrix components necessary for DNA-protein...
5.
Murthi K, Friedman L, Oleinick N, Salomon R
Biochemistry
. 1993 Apr;
32(15):4090-7.
PMID: 8471616
Levuglandin E2 (LGE2), a rearrangement product derived from the prostaglandin endoperoxide, PGH2, causes repair-resistant DNA-protein cross-links and cell death (LD50 = 230 nM) in V79 Chinese hamster lung fibroblasts. The...
6.
Chiu S, Xue L, Friedman L, Oleinick N
Radiat Res
. 1992 Feb;
129(2):184-91.
PMID: 1734449
Chromatin has been prepared from Chinese hamster V79 cell nuclei by successive suspension and sedimentation in buffers of decreasing ionic strength. For buffer concentrations from 50 to 1 mM, the...
7.
Ramakrishnan N, Clay M, Friedman L, Antunez A, Oleinick N
Photochem Photobiol
. 1990 Sep;
52(3):555-9.
PMID: 2284348
The interaction of chloroaluminum phthalocyanine-sensitized photodynamic treatment and gamma-irradiation was studied in confluent murine L929 fibroblasts. When the cells were given the combined treatments and immediately subcultured for determination of...
8.
Chiu S, Friedman L, Oleinick N
Int J Radiat Biol
. 1990 Aug;
58(2):235-47.
PMID: 1974572
The induction of DNA-protein crosslinks (DPC) was compared in gamma-irradiated metaphase and asynchronous Chinese hamster V79 cells. Unirradiated metaphase cells were found to have a higher level of background DPC...
9.
Chiu S, Friedman L, Oleinick N
Radiat Res
. 1989 Dec;
120(3):545-51.
PMID: 2594973
The production and removal of gamma-radiation-induced DNA-protein crosslinks (DPC) in nuclear matrix-associated newly replicated DNA were examined, as well as the relationship of DPC to DNA replication. In unirradiated, exponentially...
10.
Chiu S, Xue L, Friedman L, Oleinick N
Cancer Res
. 1989 Feb;
49(4):910-4.
PMID: 2912561
The antitumor agent 4'-(9-acridinylamino)methanesulfon-m-anisidide (m-AMSA) inhibits topoisomerase II activity through the formation of a complex of DNA and covalently bound enzyme which, upon protein denaturation, yields DNA breaks (single strand...