L J Guilbert
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Explore the profile of L J Guilbert including associated specialties, affiliations and a list of published articles.
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82
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1765
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Recent Articles
1.
Riddell M, Winkler-Lowen B, Chakrabarti S, Dunk C, Davidge S, Guilbert L
Placenta
. 2012 Jan;
33(3):143-50.
PMID: 22230251
The placenta is a highly vascularized organ thus angiogenesis is a key process in placental development. The contribution that different cells in the villous stroma play in placental angiogenesis is...
2.
Riddell M, Winkler-Lowen B, Guilbert L
Placenta
. 2011 Dec;
33(2):88-93.
PMID: 22133578
Apoptosis is postulated to be a delayed but important part of the differentiation of placental villous cytotrophoblasts (CT) into functional syncytiotrophoblast (ST). This hypothesis is based on the observation that...
3.
Groesch K, Torry R, Wilber A, Abrams R, Bieniarz A, Guilbert L, et al.
Placenta
. 2011 Oct;
32(12):926-31.
PMID: 21963217
Objectives: Preeclampsia is associated with reduced trophoblast placenta growth factor (PGF) expression, elevated soluble fms-like tyrosine kinase-1 (sFlt-1) and decreased bioactivity of nitric oxide (NO). Elevated sFlt-1 reduces bio-availability of...
4.
Guilbert L, Riddell M, Winkler-Lowen B
Placenta
. 2010 Sep;
31(11):982-8.
PMID: 20870287
The villous trophoblast renews itself by fusion of individual stem cells (cytotrophoblasts, CT) with a functional syncytium (syncytiotrophoblast, ST). The literature indicates that fusion occurs with limited activation (proteolytic cleavage)...
5.
Chaudhuri S, Lowen B, Chan G, Davey A, Riddell M, Guilbert L
Placenta
. 2009 Oct;
30(11):994-1001.
PMID: 19796811
Placentae from newborns with congenital human cytomegalovirus (HCMV) infection often display shallow implantation, chronic villitis and disruptions of the syncytiotrophoblast. Little is known about how HCMV infection induces inflammation in...
6.
Newhouse S, Davidge S, Winkler-Lowen B, Demianczuk N, Guilbert L
Placenta
. 2007 Jun;
28(10):999-1003.
PMID: 17559930
Highly purified (>99.99%) primary villous cytotrophoblasts from uncomplicated pregnancies and pregnancies complicated with intrauterine growth restriction (IUGR) alone, IUGR with pre-eclampsia (IUGR-PE) and PE alone were cultured for 5days and...
7.
Kilani R, Mackova M, Davidge S, Winkler-Lowen B, Demianczuk N, Guilbert L
Reproduction
. 2007 Jan;
133(1):257-64.
PMID: 17244751
Tumor necrosis factor alpha (TNFalpha) has been implicated in the abnormally high levels of trophoblast apoptosis seen in placentae from pregnancies complicated by small births. We examined the hypothesis that...
8.
Chan G, Guilbert L
J Pathol
. 2006 Jul;
210(1):111-20.
PMID: 16826536
Placentae obtained from newborns with congenital human cytomegalovirus (HCMV) infection often display chronic villitis and disruptions of the syncytiotrophoblast (ST). Little is known about how HCMV infection induces inflammation in...
9.
Guilbert L, Winkler-Lowen B
Placenta
. 2006 Jun;
28(4):348-9.
PMID: 16782189
We have further characterized villous trophoblasts isolated by trypsinization and purified by elimination of CD9/MHC class I/MHC class II expressing cells. The cells isolated were >99.99% cytotrophoblasts by criteria of...
10.
Johnstone E, Mackova M, Das S, Payne S, Lowen B, Sibley C, et al.
Placenta
. 2005 Jul;
26(7):548-55.
PMID: 15993704
Epidermal growth factor (EGF) reduces apoptosis in primary cytotrophoblast (CT) in culture through two separate pathways: the extracellular signal related kinase (ERK) 1/2 and phosphatidyl inositol 3-kinase (PI-3 kinase) paths....