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» Authors » L J Goutas

L J Goutas

Explore the profile of L J Goutas including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 7
Citations 124
Followers 0
Related Specialties
Oncology
Biochemistry
Pharmacology
Top 10 Co-Authors
F M Sirotnak
D M Moccio
L E Kelleher
J I DeGraw
L S Mines
L L Samuels
R L Kisliuk
J R Barrueco
D G Priest
F A Schmid
Published In
Cancer Res
Cancer Chemother Pharmacol
Biochem Pharmacol
Affiliations
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Recent Articles
1.
Carrier-mediated transport of folate compounds in L1210 cells. Initial rate kinetics and extent of duality of entry routes for folic acid and diastereomers of 5-methyltetrahydrohomofolate in the presence of physiological anions
Sirotnak F, Goutas L, Jacobsen D, Mines L, Barrueco J, Gaumont Y, et al.
Biochem Pharmacol . 1987 May; 36(10):1659-67. PMID: 3593392
Comparison of the kinetic parameters for influx of highly purified [3H]folic acid versus [3H]methotrexate in L1210 cells under anionic buffer conditions showed a marked discordancy. In addition, the kinetics for...
2.
Hydrolytic cleavage of methotrexate gamma-polyglutamates by folylpolyglutamyl hydrolase derived from various tumors and normal tissues of the mouse
Samuels L, Goutas L, Priest D, Piper J, Sirotnak F
Cancer Res . 1986 May; 46(5):2230-5. PMID: 2421872
Folylpolyglutamate hydrolase (folyl hydrolase) activity derived from murine tumors and various normal tissues was measured by means of high performance liquid chromatography using methotrexate polyglutamates as substrate. Enzyme-mediated hydrolysis was...
3.
Extent of the requirement for folate transport by L1210 cells for growth and leukemogenesis in vivo
Sirotnak F, Goutas L, Mines L
Cancer Res . 1985 Oct; 45(10):4732-4. PMID: 3875399
In these studies the extent of the requirement for 5-methyltetrahydrofolate by L1210 cells for growth and leukemogenesis in vivo was addressed from the aspect of its cellular membrane transport. Growth...
4.
New folate analogs of the 10-deaza-aminopterin series. Further evidence for markedly increased antitumor efficacy compared with methotrexate in ascitic and solid murine tumor models
Sirotnak F, DeGraw J, Schmid F, Goutas L, Moccio D
Cancer Chemother Pharmacol . 1984 Jan; 12(1):26-30. PMID: 6690070
A group of folate analogs of the 10-deaza-aminopterin series, which were designed on the basis of the results of an intensive biochemical and pharmacokinetic program, have been examined in therapy...
5.
New folate analogs of the 10-deaza-aminopterin series. Basis for structural design and biochemical and pharmacologic properties
Sirotnak F, DeGraw J, Moccio D, Samuels L, Goutas L
Cancer Chemother Pharmacol . 1984 Jan; 12(1):18-25. PMID: 6690069
Structural modification of the N10 position of 4-amino folates affects mediated membrane transport in mammalian cells but has little or no effect on target enzyme (dihydrofolate reductase) inhibition. Some of...
6.
Biochemical correlates of responsiveness and collateral sensitivity of some methotrexate-resistant murine tumors to the lipophilic antifolate, metoprine
Sirotnak F, Moccio D, Goutas L, Kelleher L, Montgomery J
Cancer Res . 1982 Mar; 42(3):924-8. PMID: 7059991
The M5076 murine "ovarian" tumor which is naturally refractive to methotrexate was found to be highly responsive to the lipophilic antifolate, metoprine. M5076 cells were markedly deficient in mediated entry...
7.
Relative frequency and kinetic properties of transport-defective phenotypes among methotrexate-resistant L1210 clonal cell lines derived in vivo
Sirotnak F, Moccio D, Kelleher L, Goutas L
Cancer Res . 1981 Nov; 41(11 Pt 1):4447-52. PMID: 7306968
Information was sought on the relative extent to which transport-defective, methotrexate-resistant phenotypes emerge among the total subpopulation of resistant phenotypes during therapeutic challenge of leukemic cells in vivo. A number...