L G Durrant
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Explore the profile of L G Durrant including associated specialties, affiliations and a list of published articles.
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86
Citations
766
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Recent Articles
1.
Lande R, Palazzo R, Gestermann N, Jandus C, Falchi M, Spadaro F, et al.
Sci Rep
. 2020 Apr;
10(1):5851.
PMID: 32245990
LL37 exerts a dual pathogenic role in psoriasis. Bound to self-DNA/RNA, LL37 licenses autoreactivity by stimulating plasmacytoid dendritic cells-(pDCs)-Type I interferon (IFN-I) and acts as autoantigen for pathogenic Th17-cells. In...
2.
Brentville V, Vankemmelbeke M, Metheringham R, Durrant L
Semin Immunol
. 2020 Jan;
47:101393.
PMID: 31932199
Under conditions of cellular stress, proteins can be post-translationally modified causing them to be recognized by the immune system. One such stress-induced post-translational modification (siPTM) is citrullination, the conversion of...
3.
Popple A, Durrant L, Spendlove I, Rolland P, Scott I, Deen S, et al.
Br J Cancer
. 2012 Mar;
106(7):1306-13.
PMID: 22415233
Background: The chemokine CXCL12 and its cognate receptor, CXCR4, have been implicated in numerous tumour types where expression promotes tumour growth, angiogenesis, metastasis and suppresses tumour immunity. Methods: Using a...
4.
Durrant L, Noble P, Spendlove I
Clin Exp Immunol
. 2012 Jan;
167(2):206-15.
PMID: 22235996
Research into aberrant glycosylation and over-expression of glycolipids on the surface of the majority of cancers, coupled with a knowledge of glycolipids as functional molecules involved in a number of...
5.
Baxendale A, van Hooff P, Durrant L, Spendlove I, Howdle S, Woods H, et al.
Int J Pharm
. 2011 May;
413(1-2):147-54.
PMID: 21554938
Single shot vaccines of tetanus toxoid (TT) were manufactured using the NanoMix process - a low temperature solvent free encapsulation technology using supercritical fluids. The formulations were injected into mice,...
6.
Durrant L, Buckley T
Methods Mol Med
. 2011 Mar;
4:301-11.
PMID: 21359712
In the past there was considerable evidence that cellular rather than antibody responses were more effective for tumor rejection (1). However, the task of identifying the tumor antigens recognized by...
7.
Metheringham R, Pudney V, Gunn B, Towey M, Spendlove I, Durrant L
MAbs
. 2010 Jan;
1(1):71-85.
PMID: 20046577
Antigen/antibody complexes can efficiently target antigen presenting cells to allow stimulation of the cellular immune response. Due to the difficulty of manufacture and their inherent instability complexes have proved inefficient...
8.
Ahmed M, Al-Attar A, Kim J, Watson N, Scholefield J, Durrant L, et al.
J Clin Pathol
. 2009 Dec;
62(12):1117-22.
PMID: 19946098
Background And Aims: The putative stem cell marker CD24 is a small, heavily glycosylated, cell surface molecule which was originally associated with tumour metastasis. Recently it has been reported to...
9.
Shehata M, Mukherjee A, Deen S, Al-Attar A, Durrant L, Chan S
Br J Cancer
. 2009 Sep;
101(8):1321-8.
PMID: 19755991
Background: Loss of HLA class I is important in ovarian cancer prognosis but its role as a prognostic indicator in relation to therapy remains unproven. We studied the prognostic potential...
10.
Ullenhag G, Spendlove I, Watson N, Kallmeyer C, Pritchard-Jones K, Durrant L
Clin Immunol
. 2008 May;
128(2):148-54.
PMID: 18508409
We assessed T-cell responses in young osteosarcoma patients vaccinated with 105AD7, 1-6 months after having received chemotherapy. 105AD7 is a human anti-idiotypic antibody mimicking CD55, a glycoprotein that protects from...