L E Purton
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Explore the profile of L E Purton including associated specialties, affiliations and a list of published articles.
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12
Citations
309
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Recent Articles
1.
Green A, Kocovski P, Jovic T, Walia M, Chandraratna R, Martin T, et al.
Exp Cell Res
. 2016 Dec;
350(1):284-297.
PMID: 27964926
Low and high serum retinol levels are associated with increased fracture risk and poor bone health. We recently showed retinoic acid receptors (RARs) are negative regulators of osteoclastogenesis. Here we...
2.
Bhattacharya S, Chalk A, Ng A, Martin T, Zannettino A, Purton L, et al.
Oncogene
. 2016 Apr;
35(40):5282-5294.
PMID: 27041566
Osteosarcoma (OS) is the most common cancer of bone and the 5th leading cause of cancer-related death in young adults. Currently, 5-year survival rates have plateaued at ~70% for patients...
3.
Chee L, Hendy J, Purton L, McArthur G
Leukemia
. 2012 Dec;
27(6):1369-80.
PMID: 23228968
All-trans retinoic acid (ATRA) is used successfully in the treatment of acute promyelocytic leukemia (APL). ATRA enhances hematopoietic stem cell self-renewal through retinoic acid receptor (RAR)γ activation while promoting differentiation...
4.
Tug of war in the haematopoietic stem cell niche: do myeloma plasma cells compete for the HSC niche?
Noll J, Williams S, Purton L, Zannettino A
Blood Cancer J
. 2012 Sep;
2:e91.
PMID: 22983434
In the adult mammal, normal haematopoiesis occurs predominantly in the bone marrow, where primitive haematopoietic stem cells (HSC) and their progeny reside in specialised microenvironments. The bone marrow microenvironment contains...
5.
Purton L, Morris J, Bernstein I, Collins S, Kiem H
J Hematother Stem Cell Res
. 2002 Jan;
10(6):815-25.
PMID: 11798508
A major limiting factor in achieving high levels of gene transfer into hematopoietic stem cells is the ability to retain significant repopulating activity of the stem cells during the ex...
6.
Collins S, Ulmer J, Purton L, Darlington G
Blood
. 2001 Oct;
98(8):2382-8.
PMID: 11588034
The transcription factor C/EBPalpha is an important mediator of granulocyte differentiation and regulates the expression of multiple granulocyte-specific genes including the granulocyte-colony-stimulating factor (G-CSF) receptor, neutrophil elastase, and myeloperoxidase. Indeed...
7.
Purton L, Bernstein I, Collins S
Blood
. 2000 Jan;
95(2):470-7.
PMID: 10627451
The retinoic acid receptor (RAR) agonist, all-trans retinoic acid (ATRA), is a potent inducer of terminal differentiation of malignant promyelocytes, but its effects on more primitive hematopoietic progenitors and stem...
8.
Purton L, Bernstein I, Collins S
Blood
. 1999 Jul;
94(2):483-95.
PMID: 10397716
All-trans retinoic acid (ATRA) is a potent inducer of terminal differentiation of malignant promyelocytes, but its effects on more primitive hematopoietic progenitors and stem cells are less clear. In this...
9.
Purton L, Mielcarek M, Torok-Storb B
Bone Marrow Transplant
. 1998 Jun;
21(10):1075-6.
PMID: 9632285
No abstract available.
10.
Varnum-Finney B, Purton L, Yu M, Brashem-Stein C, Flowers D, Staats S, et al.
Blood
. 1998 May;
91(11):4084-91.
PMID: 9596653
We examined the expression of two members of the Notch family, Notch-1 and Notch-2, and one Notch ligand, Jagged-1, in hematopoietic cells. Both Notch-1 and Notch-2 were detected in murine...