L E Pritchard
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Explore the profile of L E Pritchard including associated specialties, affiliations and a list of published articles.
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Articles
15
Citations
999
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0
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Recent Articles
1.
Whalley N, Pritchard L, Smith D, White A
J Endocrinol
. 2011 Jul;
211(1):99-106.
PMID: 21795304
Proglucagon is cleaved to glucagon by prohormone convertase 2 (PC2) in pancreatic α-cells, but is cleaved to glucagon-like peptide-1 (GLP-1) by PC1 in intestinal L-cells. The aim of this study...
2.
Murray P, Read A, Banerjee I, Whatmore A, Pritchard L, Davies R, et al.
Eur J Endocrinol
. 2011 Feb;
164(4):521-7.
PMID: 21296922
Introduction: Leptin deficiency caused by mutations within the leptin gene (LEP) results in severe early onset obesity, hypogonadism, pubertal delay and immune system abnormalities. Constitutional delay in growth and puberty...
3.
Gyte A, Pritchard L, Jones H, Brennand J, White A
J Neuroendocrinol
. 2007 Nov;
19(12):941-51.
PMID: 18001323
The link between obesity and diabetes is not fully understood but there is evidence to suggest that hypothalamic signalling pathways may be involved. The hypothalamic neuropeptides, pro-opiomelanocortin (POMC), neuropeptide Y...
4.
Pritchard L, Armstrong D, Davies N, Oliver R, Schmitz C, Brennand J, et al.
J Endocrinol
. 2004 Jan;
180(1):183-91.
PMID: 14709157
Interactions between pro-opiomelanocortin (POMC)-derived peptides, agouti-related protein (AGRP) and the melanocortin-4 receptor (MC4-R) are central to energy homeostasis. In this study we have undertaken comprehensive pharmacological analysis of these interactions...
5.
Pritchard L, Turnbull A, White A
J Endocrinol
. 2002 Mar;
172(3):411-21.
PMID: 11874690
Bioactive peptides derived from the prohormone, pro-opiomelanocortin (POMC), are generated in neurons of the hypothalamus and act as endogenous ligands for the melanocortin-4 receptor (MC4R), a key molecule underlying appetite...
6.
Esposito L, Hill N, Pritchard L, Cucca F, Muxworthy C, Merriman M, et al.
Diabetes
. 1998 Oct;
47(11):1797-9.
PMID: 9792551
No abstract available.
7.
Mein C, Esposito L, Dunn M, Johnson G, Timms A, Goy J, et al.
Nat Genet
. 1998 Jul;
19(3):297-300.
PMID: 9662409
Genetic analysis of a mouse model of major histocompatability complex (MHC)-associated autoimmune type 1 (insulin-dependent) diabetes mellitus (IDDM) has shown that the disease is caused by a combination of a...
8.
Nistico L, Buzzetti R, Pritchard L, Van der Auwera B, Giovannini C, Bosi E, et al.
Hum Mol Genet
. 1996 Jul;
5(7):1075-80.
PMID: 8817351
Susceptibility to autoimmune insulin-dependent (type 1) diabetes mellitus is determined by a combination of environmental and genetic factors, which include variation in MHC genes on chromosome 6p21 (IDDM1) and the...
9.
Gough S, Saker P, Pritchard L, Merriman T, Merriman M, Rowe B, et al.
Hum Mol Genet
. 1995 Sep;
4(9):1609-12.
PMID: 8541847
Recent evidence suggests that a mutation of the glucagon receptor (GCG-R) gene is involved in the development of type 2 diabetes in French patients. We have examined patients from three...
10.
Bennett S, Lucassen A, Gough S, Powell E, Undlien D, Pritchard L, et al.
Nat Genet
. 1995 Mar;
9(3):284-92.
PMID: 7773291
The IDDM2 locus encoding susceptibility to type 1 diabetes was mapped previously to a 4.1-kb region spanning the insulin gene and a minisatellite or variable number of tandem repeats (VNTR)...