L D Middaugh
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Explore the profile of L D Middaugh including associated specialties, affiliations and a list of published articles.
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82
Citations
748
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Recent Articles
1.
Boger H, Mannangatti P, Samuvel D, Saylor A, Bender T, McGinty J, et al.
Genes Brain Behav
. 2010 Sep;
10(2):186-98.
PMID: 20860702
Brain-derived neurotrophic factor (BDNF) is critical in synaptic plasticity and in the survival and function of midbrain dopamine neurons. In this study, we assessed the effects of a partial genetic...
2.
Griffin 3rd W, Randall P, Middaugh L
Pharmacol Biochem Behav
. 2007 Jun;
87(2):267-79.
PMID: 17561241
This study examined individual differences in male and female C57BL/6J (C57) mice responding for intravenous cocaine reinforcement. The experiment used 4 groups of mice, distinguished by sex and cocaine unit...
3.
Griffin 3rd W, Middaugh L, Tyor W
Brain Res
. 2006 Dec;
1134(1):214-9.
PMID: 17189621
Clinical and preclinical evidence suggests that cocaine exposure hastens progression of the HIV disease process. An established active, euphoric dose of cocaine (20 mg/kg) was administered to SCID mice according...
4.
Boger H, Middaugh L, Huang P, Zaman V, Smith A, Hoffer B, et al.
Exp Neurol
. 2006 Aug;
202(2):336-47.
PMID: 16889771
Glial cell line-derived neurotrophic factor (GDNF) is a trophic factor for peripheral organs, spinal cord, and midbrain dopamine (DA) neurons. Levels of GDNF deteriorate in the substantia nigra in Parkinson's...
5.
Griffin 3rd W, Boger H, Granholm A, Middaugh L
Brain Res
. 2005 Dec;
1068(1):257-60.
PMID: 16364262
Glial cell line derived neurotrophic factor (GDNF) has been reported to alter the reward value of abused substances such as alcohol and cocaine as well as neural circuitry underlying reward....
6.
Griffin 3rd W, Middaugh L
Synapse
. 2005 Nov;
59(2):74-81.
PMID: 16270301
C57BL6/J (C57) mice serve as a useful animal model of cocaine abuse because they self-administer cocaine, exhibit place conditioning to cocaine, discriminate the interoceptive cues of cocaine, and are used...
7.
Szumlinski K, Lominac K, Frys K, Middaugh L
Genes Brain Behav
. 2005 Jul;
4(5):324-36.
PMID: 16011579
Substantial interindividual variability exists in the propensity to develop opiate addiction. Genetic variation in opiate reward may contribute to this variability. A large body of evidence indicates genetic variation in...
8.
Griffin 3rd W, Middaugh L
Pharmacol Biochem Behav
. 2003 Dec;
76(3-4):543-9.
PMID: 14643854
The purpose of this study was to determine (1) if C57BL/6J (C57) mice would lever-press for intravenous cocaine infusions in a limited-access paradigm without previously establishing the instrumental response with...
9.
Middaugh L, Bandy A
Psychopharmacology (Berl)
. 2000 Oct;
151(4):321-7.
PMID: 11026738
Rationale: The conditions under which naltrexone reduces ethanol consumption and its effect on behavior controlled by ethanol conditioned stimuli remain unclear. Objectives: The objectives were to determine the effects of...
10.
Middaugh L, Lee A, Bandy A
Alcohol Clin Exp Res
. 2000 Sep;
24(8):1172-9.
PMID: 10968654
Background: Operant experiments which indicate that ethanol can serve as a reinforcer to maintain lever responding during limited periods of access have not been conducted on non-food-deprived mice, as they...