L Ashley Blackshaw
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Explore the profile of L Ashley Blackshaw including associated specialties, affiliations and a list of published articles.
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76
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2317
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Recent Articles
11.
Peiris M, Aktar R, Raynel S, Hao Z, Mumphrey M, Berthoud H, et al.
Nutrients
. 2018 Oct;
10(10).
PMID: 30336615
Background: Nutrient-sensing receptors located on enteroendocrine (EEC) cells modulate appetite via detection of luminal contents. Colonic 'tasting' of luminal contents may influence changes to appetite observed in obesity and after...
12.
Aktar R, Peiris M, Fikree A, Cibert-Goton V, Walmsley M, Tough I, et al.
J Physiol
. 2018 Jun;
596(17):4237-4251.
PMID: 29917237
Key Points: Tenascin-X (TNX) is an extracellular matrix glycoprotein with anti-adhesive properties in skin and joints. Here we report the novel finding that TNX is expressed in human and mouse...
13.
Woodland P, Shen Ooi J, Grassi F, Nikaki K, Lee C, Evans J, et al.
Gastroenterology
. 2017 Jul;
153(5):1230-1239.
PMID: 28734832
Background & Aims: Little is known about the causes of heartburn in patients with gastro-esophageal reflux disease. Visible epithelial damage is seldom associated with symptom severity, evidenced by the significant...
14.
Peiris M, Hockley J, Reed D, Smith E, Bulmer D, Blackshaw L
Mol Pain
. 2017 Jun;
13:1744806917709371.
PMID: 28566000
Background Chronic visceral pain is a defining symptom of many gastrointestinal disorders. The K7 family (K7.1-K7.5) of voltage-gated potassium channels mediates the M current that regulates excitability in peripheral sensory...
15.
Campaniello M, Mavrangelos C, Eade S, Harrington A, Blackshaw L, Brierley S, et al.
Brain Behav Immun
. 2016 Nov;
60:319-332.
PMID: 27864046
Objective: Little is understood regarding how disease progression alters immune and sensory nerve function in colitis. We investigated how acute colitis chronically alters immune recruitment and the impact this has...
16.
Brierley S, Hughes P, Harrington A, Rychkov G, Blackshaw L
Pharmaceuticals (Basel)
. 2016 Oct;
3(9):2768-2798.
PMID: 27713376
We are normally unaware of the complex signalling events which continuously occur within our internal organs. Most of us only become cognisant when sensations of hunger, fullness, urgency or gas...
17.
McGuire C, Boundouki G, Hockley J, Reed D, Cibert-Goton V, Peiris M, et al.
Gut
. 2016 Sep;
67(1):86-96.
PMID: 27654583
Objective: The development of effective visceral analgesics free of deleterious gut-specific side effects is a priority. We aimed to develop a reproducible methodology to study visceral nociception in human tissue...
18.
Hockley J, Tranter M, McGuire C, Boundouki G, Cibert-Goton V, Thaha M, et al.
J Neurosci
. 2016 Feb;
36(8):2364-76.
PMID: 26911685
Activation of visceral nociceptors by inflammatory mediators contributes to visceral hypersensitivity and abdominal pain associated with many gastrointestinal disorders. Purine and pyrimidine nucleotides (e.g., ATP and UTP) are strongly implicated...
19.
Campaniello M, Harrington A, Martin C, Blackshaw L, Brierley S, Hughes P
Neurogastroenterol Motil
. 2015 Oct;
28(1):54-63.
PMID: 26468044
Background: Chronic visceral pain is a defining feature of irritable bowel syndrome (IBS). IBS patients often show alterations in innate and adaptive immune function which may contribute to symptoms. Immune...
20.
Woodland P, Aktar R, Mthunzi E, Lee C, Peiris M, Preston S, et al.
Am J Physiol Gastrointest Liver Physiol
. 2015 Jan;
308(6):G525-31.
PMID: 25573174
Little is known about the mucosal phenotype of the proximal human esophagus. There is evidence to suggest that the proximal esophagus is more sensitive to chemical and mechanical stimulation compared...