L A J ONeill
Overview
Explore the profile of L A J ONeill including associated specialties, affiliations and a list of published articles.
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Articles
15
Citations
2874
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0
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Recent Articles
1.
McGettrick A, Bourner L, Dorsey F, ONeill L
Nat Metab
. 2024 Jul;
6(9):1661-1667.
PMID: 39060560
The metabolite itaconate has emerged as an important immunoregulator with roles in antibacterial defence, inhibition of inflammation and, more recently, as an inhibitory factor in obesity. Itaconate is one of...
2.
Kelly L, ODea M, Zareen Z, Melo A, McKenna E, Strickland T, et al.
Clin Exp Immunol
. 2021 Mar;
205(1):89-97.
PMID: 33768526
Neonatal encephalopathy (NE) is characterized by altered neurological function in term infants and inflammation plays an important pathophysiological role. Inflammatory cytokines interleukin (IL)-1β, IL-1ra and IL-18 are activated by the...
3.
Diskin C, Ryan T, ONeill L
Immunity
. 2020 Nov;
54(1):19-31.
PMID: 33220233
Immunometabolism has emerged as a key focus for immunologists, with metabolic change in immune cells becoming as important a determinant for specific immune effector responses as discrete signaling pathways. A...
4.
Dempsey C, Rubio Araiz A, Bryson K, Finucane O, Larkin C, Mills E, et al.
Brain Behav Immun
. 2016 Dec;
61:306-316.
PMID: 28003153
Activation of the inflammasome is implicated in the pathogenesis of an increasing number of inflammatory diseases, including Alzheimer's disease (AD). Research reporting inflammatory changes in post mortem brain tissue of...
5.
McGettrick A, ONeill L
Diabetes Obes Metab
. 2013 Sep;
15 Suppl 3:19-25.
PMID: 24003917
The activation of the NLRP3 inflammasome leads to the autocleavage and activation of caspase-1. Caspase-1 cleaves several substrates, including the pro-inflammatory cytokine IL-1β. Inflammation, in particular IL-1β, has long been...
6.
Haneklaus M, Gerlic M, ONeill L, Masters S
J Intern Med
. 2013 Jun;
274(3):215-26.
PMID: 23772809
Expression of the microRNA miR-223 is deregulated during influenza or hepatitis B infection and in inflammatory bowel disease, type 2 diabetes, leukaemia and lymphoma. Although this may also be the...
7.
Corr S, Palsson-McDermott E, Grishina I, Barry S, Aviello G, Bernard N, et al.
Mucosal Immunol
. 2013 Apr;
7(1):57-67.
PMID: 23612054
MyD88 adapter-like (Mal)-deficient mice displayed increased susceptibility to oral but not intraperitoneal infection with Salmonella Typhimurium. Bone marrow chimeras demonstrated that mice with Mal-deficient non-hematopoietic cells were more susceptible to...
8.
Tannahill G, Curtis A, Adamik J, Palsson-McDermott E, McGettrick A, Goel G, et al.
Nature
. 2013 Mar;
496(7444):238-42.
PMID: 23535595
Macrophages activated by the Gram-negative bacterial product lipopolysaccharide switch their core metabolism from oxidative phosphorylation to glycolysis. Here we show that inhibition of glycolysis with 2-deoxyglucose suppresses lipopolysaccharide-induced interleukin-1β but...
9.
Lavelle E, Murphy C, ONeill L, Creagh E
Mucosal Immunol
. 2009 Nov;
3(1):17-28.
PMID: 19890268
The mucosal surfaces of the gastrointestinal tract are continually exposed to an enormous antigenic load of microbial and dietary origin, yet homeostasis is maintained. Pattern recognition molecules (PRMs) have a...
10.
Sheedy F, ONeill L
Ann Rheum Dis
. 2008 Dec;
67 Suppl 3:iii50-5.
PMID: 19022814
MicroRNAs (miRNAs) are recently discovered regulators of gene expression, and early studies have indicated that they have a role in the regulation of haematopoiesis, the immune response and inflammation. They...