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L A Hyde

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Articles 28
Citations 387
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Recent Articles
1.
Hutson P, Finger E, Magliaro B, Smith S, Converso A, Sanderson P, et al.
Neuropharmacology . 2011 May; 61(4):665-76. PMID: 21619887
Inhibition of phosphodiesterase 9 (PDE9) has been reported to enhance rodent cognitive function and may represent a potential novel approach to improving cognitive dysfunction in Alzheimer's disease. PF-04447943, (6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one), a...
2.
Varty G, Hyde L, Hodgson R, Lu S, McCool M, Kazdoba T, et al.
Psychopharmacology (Berl) . 2005 Jul; 182(1):132-43. PMID: 16025321
Rationale: Previous studies have demonstrated behaviors indicative of anxiolysis in rats pretreated with the nociceptin receptor (opioid receptor like-1, ORL-1) agonist, Ro64-6198. Objectives: The aim of this study was to...
3.
Kowalski T, Spar B, Markowitz L, Maguire M, Golovko A, Yang S, et al.
J Endocrinol . 2005 Apr; 185(1):151-64. PMID: 15817836
Recent work has shown that neuromedin U (NmU), a peptide initially identified as a smooth muscle contractor, may play a role in regulating food intake and energy homeostasis. To further...
4.
Hyde L, Crnic L
Behav Neurosci . 2002 Jan; 115(6):1239-46. PMID: 11770055
All individuals with Down syndrome (DS) eventually develop the neuropathology of Alzheimer's disease (AD), which is characterized by a premature loss of basal forebrain cholinergic neurons. Similarly, between 4 and...
5.
Hyde L, Hoplight B, Harding S, SHERMAN G, Mobraaten L, Denenberg V
Dev Psychobiol . 2001 Dec; 39(4):286-300. PMID: 11745324
About half of BXSB/MpJ-Yaa mice have ectopias, which are misplaced clusters of neurons located in layer I of cortex. This study replicated several previous findings showing that there are learning...
6.
Hoplight B, SHERMAN G, Hyde L, Denenberg V
Neurobiol Learn Mem . 2001 Aug; 76(1):33-45. PMID: 11525251
Approximately 40-60% of BXSB mice have neocortical ectopias, a developmental anomaly characterized by migration of neurons into the neuron-sparse layer I of cortex. Previous studies have shown that ectopic BXSB...
7.
Hyde L, Frisone D, Crnic L
Behav Brain Res . 2001 Feb; 118(1):53-60. PMID: 11163633
The Ts65Dn mouse is segmentally trisomic for a part of mouse chromosome 16 and is a genetic model for Down syndrome and Alzheimer's disease. Although many studies have examined the...
8.
Hyde L, Crnic L, Pollock A, Bickford P
Dev Psychobiol . 2001 Jan; 38(1):33-45. PMID: 11150059
Ts65Dn mice are a genetic model for Down syndrome. Both individuals with Down syndrome and Ts65Dn mice have reduced cerebellar volumes and the cerebellum is involved in motor learning. Conflicting...
9.
Balogh S, Waters N, Hyde L, McDowell C, Casler C, Denenberg V, et al.
Brain Res . 2001 Jan; 887(2):484-7. PMID: 11134648
Previous studies have shown that autoimmune mice perform very poorly on active avoidance learning tasks. In the current studies, mice with lupus-like systemic autoimmunity were able to learn active, as...
10.
Hyde L, SHERMAN G, Stavnezer A, Denenberg V
Brain Res . 2001 Jan; 887(2):482-3. PMID: 11134647
No abstract available.