Kyra Kerkhofs
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Explore the profile of Kyra Kerkhofs including associated specialties, affiliations and a list of published articles.
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6
Citations
9
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Recent Articles
1.
Kerkhofs K, Guydosh N, Bayfield M
bioRxiv
. 2024 Aug;
PMID: 39131278
Viral infection often triggers eukaryotic initiator factor 2α (eIF2α) phosphorylation, leading to global 5'-cap-dependent translation inhibition. RSV encodes messenger RNAs (mRNAs) mimicking 5'-cap structures of host mRNAs and thus inhibition...
2.
Mattijssen S, Kerkhofs K, Stephen J, Yang A, Han C, Tadafumi Y, et al.
bioRxiv
. 2024 Feb;
PMID: 38410490
RNA polymerase III (Pol III, POLR3) synthesizes tRNAs and other small non-coding RNAs. Human pathogenic variants cause a range of developmental disorders, recapitulated in part by mouse models, yet some...
3.
Miller D, Kerkhofs K, Abbas-Aghababazadeh F, Madahar S, Minden M, Hebert J, et al.
Cell Death Dis
. 2023 Aug;
14(8):503.
PMID: 37543610
Erythropoietin (EPO) suppresses drug-induced apoptosis in EPO-receptor-positive leukemia cells and allows cells to persist after drug treatment by promoting cellular senescence. Importantly a small proportion of senescent cells can re-enter...
4.
Kerkhofs K, Garg J, Fafard-Couture E, Elela S, Scott M, Pearlman R, et al.
Nat Commun
. 2022 Nov;
13(1):7332.
PMID: 36443289
Nascent pre-tRNAs are transcribed by RNA polymerase III and immediately bound by La proteins on the UUU-3'OH sequence, using a tandem arrangement of the La motif and an adjacent RNA...
5.
Bayfield M, Kerkhofs K, Mansouri-Noori F
Structure
. 2019 Dec;
27(12):1737-1739.
PMID: 31801095
LARP1 proteins integrate the translation and stability of 5'TOP mRNAs with signaling from the mTOR pathway, but the mechanism is not well understood. In this issue of Structure, Cassidy et ...
6.
Bayfield M, Vinayak J, Kerkhofs K, Mansouri-Noori F
RNA Biol
. 2019 Feb;
18(2):168-177.
PMID: 30777481
La shuttles between the nucleus and cytoplasm where it binds nascent RNA polymerase III (pol III) transcripts and mRNAs, respectively. La protects the 3' end of pol III transcribed RNA...