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Kyotaro Hirashima

Explore the profile of Kyotaro Hirashima including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 6
Citations 430
Followers 0
Related Specialties
Biochemistry
Science
General Medicine
Top 10 Co-Authors
Hiroyuki Seimiya
Tohru Kiyono
Makoto Goto
Laura Magnaghi-Jaulin
Masashige Bando
Kentaro Takagaki
Ryuichiro Nakato
Frank J Kaiser
Kazumasa Zensho
Tomoko Iwaki
Published In
Nucleic Acids Res
J Virol
Mol Cell Biol
PLoS One
Nature
Affiliations
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Recent Articles
1.
Telomeric repeat-containing RNA/G-quadruplex-forming sequences cause genome-wide alteration of gene expression in human cancer cells in vivo
Hirashima K, Seimiya H
Nucleic Acids Res . 2015 Feb; 43(4):2022-32. PMID: 25653161
Telomere erosion causes cell mortality, suggesting that longer telomeres enable more cell divisions. In telomerase-positive human cancer cells, however, telomeres are often kept shorter than those of surrounding normal tissues....
2.
Reprogramming suppresses premature senescence phenotypes of Werner syndrome cells and maintains chromosomal stability over long-term culture
Shimamoto A, Kagawa H, Zensho K, Sera Y, Kazuki Y, Osaki M, et al.
PLoS One . 2014 Nov; 9(11):e112900. PMID: 25390333
Werner syndrome (WS) is a premature aging disorder characterized by chromosomal instability and cancer predisposition. Mutations in WRN are responsible for the disease and cause telomere dysfunction, resulting in accelerated...
3.
Telomere length influences cancer cell differentiation in vivo
Hirashima K, Migita T, Sato S, Muramatsu Y, Ishikawa Y, Seimiya H
Mol Cell Biol . 2013 May; 33(15):2988-95. PMID: 23716593
Limitless reproductive potential is one of the hallmarks of cancer cells. This ability is due to the maintenance of telomeres, erosion of which causes cellular senescence or death. While most...
4.
HDAC8 mutations in Cornelia de Lange syndrome affect the cohesin acetylation cycle
Deardorff M, Bando M, Nakato R, Watrin E, Itoh T, Minamino M, et al.
Nature . 2012 Aug; 489(7415):313-7. PMID: 22885700
Cornelia de Lange syndrome (CdLS) is a dominantly inherited congenital malformation disorder, caused by mutations in the cohesin-loading protein NIPBL for nearly 60% of individuals with classical CdLS, and by...
5.
A simple and effective chromosome modification method for large-scale deletion of genome sequences and identification of essential genes in fission yeast
Hirashima K, Iwaki T, Takegawa K, Giga-Hama Y, Tohda H
Nucleic Acids Res . 2006 Jan; 34(2):e11. PMID: 16434698
The technologies for chromosome modification developed to date are not satisfactorily universal, owing to the typical requirements for special enzymes and sequences. In the present report, we propose a new...
6.
RNA helicase domain of tobamovirus replicase executes cell-to-cell movement possibly through collaboration with its nonconserved region
Hirashima K, Watanabe Y
J Virol . 2003 Oct; 77(22):12357-62. PMID: 14581573
UR-hel, a chimeric virus obtained by replacement of the RNA helicase domain of tobacco mosaic virus (TMV)-U1 replicase with that from the TMV-R strain, could replicate similarly to TMV-U1 in...