Kyle Mohler
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Explore the profile of Kyle Mohler including associated specialties, affiliations and a list of published articles.
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18
Citations
252
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Recent Articles
1.
Grome M, Nguyen M, Moonan D, Mohler K, Gurara K, Wang S, et al.
Nature
. 2025 Feb;
639(8054):512-521.
PMID: 39910296
The genetic code is conserved across all domains of life, yet exceptions have revealed variations in codon assignments and associated translation factors. Inspired by this natural malleability, synthetic approaches have...
2.
Hemez C, Mohler K, Radford F, Moen J, Rinehart J, Isaacs F
bioRxiv
. 2024 Sep;
PMID: 39257802
Genomically recoded organisms hold promise for many biotechnological applications, but they may exhibit substantial fitness defects relative to their non-recoded counterparts. We used targeted metabolic screens, genetic analysis, and proteomics...
3.
Ang I, Yousafzai M, Yadav V, Mohler K, Rinehart J, Bouklas N, et al.
APL Bioeng
. 2024 May;
8(2):026109.
PMID: 38706957
During cancer pathogenesis, cell-generated mechanical stresses lead to dramatic alterations in the mechanical and organizational properties of the extracellular matrix (ECM). To date, contraction of the ECM is largely attributed...
4.
Lee S, Yousafzai M, Mohler K, Yadav V, Amiri S, Szuszkiewicz J, et al.
Mol Biol Cell
. 2023 Sep;
34(12):ar122.
PMID: 37672340
The invasive potential of glioblastoma cells is attributed to large changes in pressure and volume, driven by diverse elements, including the cytoskeleton and ion cotransporters. However, how the cell actuates...
5.
Mohler K, Moen J, Rogulina S, Rinehart J
Mol Syst Biol
. 2023 Jul;
19(8):e10591.
PMID: 37477096
Over the past two decades, synthetic biological systems have revolutionized the study of cellular physiology. The ability to site-specifically incorporate biologically relevant non-standard amino acids using orthogonal translation systems (OTSs)...
6.
Moen J, Mohler K, Rogulina S, Shi X, Shen H, Rinehart J
Nat Commun
. 2022 Nov;
13(1):7226.
PMID: 36433969
Protein phosphorylation is a ubiquitous post-translational modification used to regulate cellular processes and proteome architecture by modulating protein-protein interactions. The identification of phosphorylation events through proteomic surveillance has dramatically outpaced...
7.
Gassaway B, Li J, Rad R, Mintseris J, Mohler K, Levy T, et al.
Nat Methods
. 2022 Oct;
19(11):1371-1375.
PMID: 36280721
Mass-spectrometry-based phosphoproteomics has become indispensable for understanding cellular signaling in complex biological systems. Despite the central role of protein phosphorylation, the field still lacks inexpensive, regenerable, and diverse phosphopeptides with...
8.
Mohler K, Moen J, Rogulina S, Rinehart J
bioRxiv
. 2022 Oct;
PMID: 36203552
Interactions between proteins from intracellular pathogens and host proteins in an infected cell are often mediated by post-translational modifications encoded in the host proteome. Identifying protein modifications, such as phosphorylation,...
9.
Schiapparelli P, Pirman N, Mohler K, Miranda-Herrera P, Zarco N, Kilic O, et al.
Cell Rep
. 2021 Jul;
36(3):109416.
PMID: 34289367
Advances in genetic code expansion have enabled the production of proteins containing site-specific, authentic post-translational modifications. Here, we use a recoded bacterial strain with an expanded genetic code to encode...
10.
Wood W, Mohler K, Rinehart J, Ibba M
mBio
. 2021 Jun;
12(3):e0113221.
PMID: 34126764
Bacterial antibiotic persistence occurs when bacteria are treated with an antibiotic and the majority of the population rapidly dies off, but a small subpopulation enters into a dormant, persistent state...