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Kwang-Yu Chang

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Articles 57
Citations 977
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Recent Articles
11.
Chien C, Yang W, Chuang J, Lee J, Liao W, Huang C, et al.
J Exp Clin Cancer Res . 2022 Jul; 41(1):220. PMID: 35831908
Background: The mechanism by which glioblastoma evades temozolomide (TMZ)-induced cytotoxicity is largely unknown. We hypothesized that mitochondria plays a role in this process. Methods: RNA transcriptomes were obtained from tumor...
12.
Tsai Y, Lo W, Chen P, Ko C, Chuang J, Kao T, et al.
J Biomed Sci . 2022 Mar; 29(1):21. PMID: 35337344
Background: Sp1 is involved in the recurrence of glioblastoma (GBM) due to the acquirement of resistance to temozolomide (TMZ). Particularly, the role of Sp1 in metabolic reprogramming for drug resistance...
13.
Wu A, Yang W, Chang K, Lee J, Liou J, Su R, et al.
J Exp Clin Cancer Res . 2022 Feb; 41(1):47. PMID: 35109908
Background: Glioblastoma (GBM) is the most aggressive and lethal brain tumor. Although the histone deacetylase (HDAC)/transcription factor axis promotes growth in GBM, whether HDACs including HDAC6 are involved in modulating...
14.
Hsueh W, Chen S, Chien C, Chou S, Chi P, Chu J, et al.
Int J Mol Sci . 2021 Oct; 22(20). PMID: 34681918
The phosphoinositide-3-kinase (PI3K) pathway has widely been considered as a potential therapeutic target for head and neck cancer (HNC); however, the application of PI3K inhibitors is often overshadowed by the...
15.
Yang W, Wu A, Hsu T, Liou J, Lo W, Chang K, et al.
Cell Death Dis . 2021 Sep; 12(10):884. PMID: 34584069
DNA repair promotes the progression and recurrence of glioblastoma (GBM). However, there remain no effective therapies for targeting the DNA damage response and repair (DDR) pathway in the clinical setting....
16.
Chang K, Chiang N, Wu S, Yen C, Chen S, Yeh Y, et al.
Oncoimmunology . 2021 Jul; 10(1):1943253. PMID: 34290906
Background: Pegylated arginine deiminase (ADI-PEG 20) is a metabolism-based strategy that depletes arginine, resulting in tumoral stress and cytotoxicity. Preclinically, ADI-PEG 20 modulates T-cell activity and enhances the therapeutic efficacy...
17.
Debele T, Wu P, Wei Y, Chuang J, Chang K, Tsai J, et al.
Cancers (Basel) . 2021 Jun; 13(10). PMID: 34069106
Herein, GSH-sensitive hyaluronic acid-poly(lactic-co-glycolic acid) (HA-SS-PLGA) was synthesized. Surface modification of PLGA with hyaluronic acid produced a highly stable micelle at physiological pH while a micelle was destabilized at a...
18.
Hsu C, Liao W, Chang K, Chan T, Huang P, Chiang C, et al.
Gastric Cancer . 2021 Mar; 24(3):640-641. PMID: 33770302
No abstract available.
19.
Chien C, Hsueh W, Chuang J, Chang K
J Biomed Sci . 2021 Mar; 28(1):18. PMID: 33685470
Glioblastoma is the most common primary malignant brain tumor that is usually considered fatal even with treatment. This is often a result for tumor to develop resistance. Regarding the standard...
20.
Chen S, Hsiao S, Chang K, Chang J
Int J Mol Sci . 2021 Mar; 22(5). PMID: 33668218
Oral squamous cell carcinoma (SCC) is a prevalent malignant disease worldwide, especially so in Taiwan. Early- or even preclinical-stage detection is critical for reducing morbidity and mortality from oral SCC....