Kristyna Brejchova
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Explore the profile of Kristyna Brejchova including associated specialties, affiliations and a list of published articles.
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16
Citations
219
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Recent Articles
1.
Uncovering mechanisms of thiazolidinediones on osteogenesis and adipogenesis using spatial fluxomics
Brejchova K, Rahm M, Benova A, Domanska V, Reyes-Gutierez P, Dzubanova M, et al.
Metabolism
. 2025 Feb;
166:156157.
PMID: 39947516
Objective: Insulin-sensitizing drugs, despite their broad use against type 2 diabetes, can adversely affect bone health, and the mechanisms underlying these side effects remain largely unclear. Here, we investigated the...
2.
cajka T, Hricko J, Rakusanova S, Brejchova K, Novakova M, Rudl Kulhava L, et al.
Int J Mol Sci
. 2024 Mar;
25(5).
PMID: 38474147
Liquid chromatography with mass spectrometry (LC-MS)-based metabolomics detects thousands of molecular features (retention time-/ pairs) in biological samples per analysis, yet the metabolite annotation rate remains low, with 90% of...
3.
Brejchova K, Paluchova V, Brezinova M, cajka T, Balas L, Durand T, et al.
Food Chem
. 2022 Apr;
388:132983.
PMID: 35486985
Breast milk is a complex mixture containing underexplored bioactive lipids. We performed an observational case-control study to compare the impact of delivery mode: caesarean section (CS) and vaginal birth (VB);...
4.
Lopes M, Brejchova K, Riecan M, Novakova M, Rossmeisl M, cajka T, et al.
Cell Rep
. 2021 Oct;
37(2):109833.
PMID: 34644567
Glucose tolerance represents a complex phenotype in which many tissues play important roles and interact to regulate metabolic homeostasis. Here, we perform an analysis of C-glucose tissue distribution, which maps...
5.
Riecan M, Paluchova V, Lopes M, Brejchova K, Kuda O
Pharmacol Ther
. 2021 Aug;
231:107972.
PMID: 34453998
Fatty acid esters of hydroxy fatty acids (FAHFAs) represent a complex lipid class that contains both signaling mediators and structural components of lipid biofilms in humans. The majority of endogenous...
6.
Brejchova K, Radner F, Balas L, Paluchova V, cajka T, Chodounska H, et al.
Proc Natl Acad Sci U S A
. 2020 Dec;
118(2).
PMID: 33372146
Branched esters of palmitic acid and hydroxy stearic acid are antiinflammatory and antidiabetic lipokines that belong to a family of fatty acid (FA) esters of hydroxy fatty acids (HFAs) called...
7.
Brejchova K, Balas L, Paluchova V, Brezinova M, Durand T, Kuda O
Prog Lipid Res
. 2020 Aug;
79:101053.
PMID: 32735891
The discovery of branched fatty acid esters of hydroxy fatty acids (FAHFAs) in humans draw attention of many researches to their biological effects. Although FAHFAs were originally discovered in insects...
8.
Paluchova V, Vik A, cajka T, Brezinova M, Brejchova K, Bugajev V, et al.
Mol Nutr Food Res
. 2020 Apr;
64(11):e1901238.
PMID: 32277573
Scope: The docosahexaenoic acid ester of hydroxy linoleic acid (13-DHAHLA) is a bioactive lipid with anti-inflammatory properties from the family of fatty acid esters of hydroxy fatty acids (FAHFA). Methods...
9.
Paluchova V, Oseeva M, Brezinova M, cajka T, Bardova K, Adamcova K, et al.
Diabetes
. 2019 Dec;
69(3):300-312.
PMID: 31806624
Branched esters of palmitic acid and hydroxystearic acid (PAHSA) are anti-inflammatory and antidiabetic lipokines that connect glucose and lipid metabolism. We aimed to characterize involvement of the 5-PAHSA regioisomer in...
10.
Brejchova K, Dudakova L, Skalicka P, Dobrovolny R, Masek P, Putzova M, et al.
Invest Ophthalmol Vis Sci
. 2019 Jul;
60(8):3084-3090.
PMID: 31323090
Purpose: To report molecular genetic findings in six probands with congenital hereditary endothelial dystrophy (CHED) variably associated with hearing loss (also known as Harboyan syndrome). Furthermore, we developed a cellular...