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Kristofor J Webb

Explore the profile of Kristofor J Webb including associated specialties, affiliations and a list of published articles. Areas
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Articles 19
Citations 466
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Recent Articles
1.
Guard S, Chapnick D, Poss Z, Ebmeier C, Jacobsen J, Nemkov T, et al.
Mol Cell Proteomics . 2022 Jun; 21(10):100262. PMID: 35753663
The nonpsychoactive cannabinoid, cannabidiol (CBD), is Food and Dug Administration approved for treatment of two drug-resistant epileptic disorders and is seeing increased use among the general public, yet the mechanisms...
2.
Li J, Park J, Mayer J, Webb K, Uchikawa E, Wu J, et al.
Nat Struct Mol Biol . 2022 Apr; 29(4):357-368. PMID: 35361965
Insulin receptor (IR) signaling controls multiple facets of animal physiology. Maximally four insulins bind to IR at two distinct sites, termed site-1 and site-2. However, the precise functional roles of...
3.
Ding Y, Ball K, Webb K, Gao Y, DAlessandro A, Old W, et al.
Small . 2020 Sep; 16(41):e2003506. PMID: 32893496
Thermal shift assays (TSAs) have been extensively used to study thermodynamics of proteins and provide an efficient means to assess protein-ligand binding or protein-protein interactions. However, existing TSAs have limitations,...
4.
Ball K, Webb K, Coleman S, Cozzolino K, Jacobsen J, Jones K, et al.
Commun Biol . 2020 Feb; 3(1):75. PMID: 32060372
Most small molecule drugs act on living systems by physically interacting with specific proteins and modulating target function. Identification of drug binding targets, within the complex milieu of the human...
5.
Fu X, Sokolova V, Webb K, Old W, Park S
Proc Natl Acad Sci U S A . 2018 Dec; 115(52):13246-13251. PMID: 30530678
In the proteasome holoenzyme, the hexameric ATPases (Rpt1-Rpt6) enable degradation of ubiquitinated proteins by unfolding and translocating them into the proteolytic core particle. During early-stage proteasome assembly, individual Rpt proteins...
6.
Pegalajar-Jurado A, Fitzgerald B, Islam M, Belisle J, Wormser G, Waller K, et al.
Sci Rep . 2018 Aug; 8(1):12204. PMID: 30111850
Metabolites detectible in human biofluids are attractive biomarkers for the diagnosis of early Lyme disease (ELD), a vector-borne infectious disease. Urine represents an easily obtained clinical sample that can be...
7.
Stabell A, Meyerson N, Gullberg R, Gilchrist A, Webb K, Old W, et al.
Elife . 2018 Mar; 7. PMID: 29557779
Human dengue viruses emerged from primate reservoirs, yet paradoxically dengue does not reach high titers in primate models. This presents a unique opportunity to examine the genetics of spillover versus...
8.
Rotcheewaphan S, Belisle J, Webb K, Kim H, Spencer J, Borlee B
Microbiology (Reading) . 2016 Jul; 162(9):1651-1661. PMID: 27450520
The second messenger, bis-(3',5')-cyclic dimeric guanosine monophosphate (cyclic di-GMP), is involved in the control of multiple bacterial phenotypes, including those that impact host-pathogen interactions. Bioinformatics analyses predicted that Mycobacterium leprae,...
9.
Fonslow B, Stein B, Webb K, Xu T, Choi J, Park S, et al.
Nat Methods . 2014 Apr; 11(3):347-8. PMID: 24724171
No abstract available.
10.
Webb K, Xu T, Park S, Yates 3rd J
J Proteome Res . 2013 Apr; 12(5):2177-84. PMID: 23540446
A modified multidimensional protein identification technology (MudPIT) separation was coupled to an LTQ Orbitrap Velos mass spectrometer and used to rapidly identify the near-complete yeast proteome from a whole cell...