Kristofer Thorn
Overview
Explore the profile of Kristofer Thorn including associated specialties, affiliations and a list of published articles.
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13
Citations
339
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0
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Recent Articles
1.
Faure-Dupuy S, Jubrail J, Depierre M, Africano-Gomez K, Oberg L, Israelsson E, et al.
EMBO Rep
. 2024 Feb;
25(3):1156-1175.
PMID: 38332148
Human rhinovirus is the most frequently isolated virus during severe exacerbations of chronic respiratory diseases, like chronic obstructive pulmonary disease. In this disease, alveolar macrophages display significantly diminished phagocytic functions...
2.
Non-heme iron overload impairs monocyte to macrophage differentiation mitochondrial oxidative stress
Cui Y, Gutierrez S, Ariai S, Oberg L, Thorn K, Gehrmann U, et al.
Front Immunol
. 2022 Nov;
13:998059.
PMID: 36341326
Iron is a key element for systemic oxygen delivery and cellular energy metabolism. Thus regulation of systemic and local iron metabolism is key for maintaining energy homeostasis. Significant changes in...
3.
Agrawal K, Ong L, Monkley S, Thorn K, Israelsson E, Baturcam E, et al.
J Allergy Clin Immunol
. 2022 Aug;
150(6):1415-1426.e9.
PMID: 35917932
Background: Patients with asthma often suffer from frequent respiratory viral infections and reduced virus clearance. Lung resident memory T cells provide rapid protection against viral reinfections. Objective: Because the development...
4.
Monkley S, Krishnaswamy J, Goransson M, Clausen M, Meuller J, Thorn K, et al.
PLoS One
. 2020 Dec;
15(12):e0243807.
PMID: 33332401
Induced pluripotent stem cells (iPSC) offer the possibility to generate diverse disease-relevant cell types, from any genetic background with the use of cellular reprogramming and directed differentiation. This provides a...
5.
Naessens T, Morias Y, Hamrud E, Gehrmann U, Budida R, Mattsson J, et al.
Am J Respir Crit Care Med
. 2020 Apr;
202(4):535-548.
PMID: 32255375
Emerging evidence supports a crucial role for tertiary lymphoid organs (TLOs) in chronic obstructive pulmonary disease (COPD) progression. However, mechanisms of immune cell activation leading to TLOs in COPD remain...
6.
Odqvist L, Jevnikar Z, Riise R, Oberg L, Rhedin M, Leonard D, et al.
Ann Rheum Dis
. 2019 Jul;
78(10):1363-1370.
PMID: 31300459
Objectives: Genetic variations in (A20) de-ubiquitinase (DUB) domain increase the risk of systemic lupus erythematosus (SLE) and rheumatoid arthritis. A20 is a negative regulator of NF-κB but the role of...
7.
Winkler C, Hochdorfer T, Israelsson E, Hasselberg A, Cavallin A, Thorn K, et al.
J Allergy Clin Immunol
. 2019 Feb;
144(1):61-69.e7.
PMID: 30731124
Background: Group 2 innate lymphoid cells (ILC2s) are effective producers of IL-5 and IL-13 during allergic inflammation and bridge the innate and adaptive immune responses. ILC2 numbers are increased in...
8.
Hjorton K, Hagberg N, Israelsson E, Jinton L, Berggren O, Sandling J, et al.
Arthritis Res Ther
. 2018 Oct;
20(1):238.
PMID: 30355354
Background: In systemic lupus erythematosus (SLE), immune complexes (ICs) containing self-derived nucleic acids trigger the synthesis of proinflammatory cytokines by immune cells. We asked how an interleukin (IL)-1 receptor-associated kinase...
9.
Jevnikar Z, Ostling J, Ax E, Calven J, Thorn K, Israelsson E, et al.
J Allergy Clin Immunol
. 2018 Jun;
143(2):577-590.
PMID: 29902480
Background: Although several studies link high levels of IL-6 and soluble IL-6 receptor (sIL-6R) to asthma severity and decreased lung function, the role of IL-6 trans-signaling (IL-6TS) in asthmatic patients...
10.
Thorn K, Hovsepyan M, Bergsten P
Lipids Health Dis
. 2010 Oct;
9:108.
PMID: 20920255
Background: Stearoyl-CoA desaturase 1 (SCD1) is an ER resident enzyme introducing a double-bond in saturated fatty acids. Global knockout of SCD1 in mouse increases fatty acid oxidation and insulin sensitivity...