Kristin A Krukenberg
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Explore the profile of Kristin A Krukenberg including associated specialties, affiliations and a list of published articles.
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15
Citations
694
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Recent Articles
1.
Polka J, Krukenberg K, McDowell G
Mol Biol Cell
. 2015 Apr;
26(8):1413-5.
PMID: 25870234
There is a common misconception that the United States is suffering from a "STEM shortage," a dearth of graduates with scientific, technological, engineering, and mathematical backgrounds. In biomedical science, however,...
2.
Krukenberg K, Kim S, Tan E, Maliga Z, Mitchison T
Chem Biol
. 2015 Apr;
22(4):446-452.
PMID: 25865309
Poly(ADP-ribose) polymerase 1 (PARP1) synthesizes poly(ADP-ribose) (PAR), an essential post-translational modification whose function is important in many cellular processes including DNA damage signaling, cell death, and inflammation. All known PAR...
3.
McDowell G, Gunsalus K, MacKellar D, Mazzilli S, Pai V, Goodwin P, et al.
F1000Res
. 2015 Feb;
3:291.
PMID: 25653845
The landscape of scientific research and funding is in flux as a result of tight budgets, evolving models of both publishing and evaluation, and questions about training and workforce stability....
4.
5.
Krukenberg K, Jiang R, Steen J, Mitchison T
Cell Rep
. 2014 Sep;
8(6):1808-1818.
PMID: 25199834
Poly(ADP-ribose) polymerases (PARPs) catalyze poly(ADP-ribose) addition onto proteins, an important posttranslational modification involved in transcription, DNA damage repair, and stem cell identity. Previous studies established the activation of PARP1 in...
6.
Schneidman-Duhovny D, Rossi A, Avila-Sakar A, Kim S, Velazquez-Muriel J, Strop P, et al.
Bioinformatics
. 2012 Oct;
28(24):3282-9.
PMID: 23093611
Motivation: Structural characterization of protein interactions is necessary for understanding and modulating biological processes. On one hand, X-ray crystallography or NMR spectroscopy provide atomic resolution structures but the data collection...
7.
Tan E, Krukenberg K, Mitchison T
Anal Biochem
. 2012 Jun;
428(2):126-36.
PMID: 22743307
Poly(ADP-ribose) (pADPr) is a large, structurally complex polymer of repeating ADP-ribose units. It is biosynthesized from NAD⁺ by poly(ADP-ribose) polymerases (PARPs) and degraded to ADP-ribose by poly(ADP-ribose) glycohydrolase. pADPr is...
8.
Cunningham C, Southworth D, Krukenberg K, Agard D
Protein Sci
. 2012 Jun;
21(8):1162-71.
PMID: 22653663
Hsp90, a dimeric ATP-dependent molecular chaperone, is required for the folding and activation of numerous essential substrate "client" proteins including nuclear receptors, cell cycle kinases, and telomerase. Fundamental to its...
9.
Krukenberg K, Street T, Lavery L, Agard D
Q Rev Biophys
. 2011 Mar;
44(2):229-55.
PMID: 21414251
The ubiquitous molecular chaperone Hsp90 makes up 1-2% of cytosolic proteins and is required for viability in eukaryotes. Hsp90 affects the folding and activation of a wide variety of substrate...
10.
Street T, Krukenberg K, Rosgen J, Bolen D, Agard D
Protein Sci
. 2009 Nov;
19(1):57-65.
PMID: 19890989
Osmolytes are small molecules that play a central role in cellular homeostasis and the stress response by maintaining protein thermodynamic stability at controlled levels. The underlying physical chemistry that describes...