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Krista G Freeman

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Articles 13
Citations 397
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Recent Articles
1.
Smytheman T, Pecor T, Miller D, Ferede D, Kaur S, Harband M, et al.
Virol J . 2025 Jan; 22(1):14. PMID: 39833928
For much of the last decade, tuberculosis (TB) was the leading cause of mortality due to an infectious pathogen (Mycobacterium tuberculosis, M.tb). Approximately 1.3 million deaths in 2023 worldwide were...
2.
Freeman K, Lauer M, Jiang D, Roscher J, Sandler S, Mercado N, et al.
G3 (Bethesda) . 2024 Jul; 14(9). PMID: 39031590
Mycobacterium phage Adephagia is a cluster K phage that infects Mycobacterium smegmatis and some strains of Mycobacterium pathogens. Adephagia has a siphoviral virion morphology and is temperate. Its genome is...
3.
Podgorski J, Podgorski J, Abad L, Jacobs-Sera D, Freeman K, Brown C, et al.
bioRxiv . 2023 Nov; PMID: 37961133
Tailed bacteriophages are one of the most numerous and diverse group of viruses. They store their genome at quasi-crystalline densities in capsids built from multiple copies of proteins adopting the...
4.
Binsabaan S, Freeman K, Hatfull G, VanDemark A
J Mol Biol . 2023 Sep; 435(20):168261. PMID: 37678706
Approximately 70% of bacteriophage-encoded proteins are of unknown function. Elucidating these protein functions represents opportunities to discover new phage-host interactions and mechanisms by which the phages modulate host activities. Here,...
5.
Freeman K, Robotham A, Parks O, Abad L, Jacobs-Sera D, Lauer M, et al.
Cell Host Microbe . 2023 Jun; 31(7):1216-1231.e6. PMID: 37329881
Glycosylation of eukaryotic virus particles is common and influences their uptake, trafficking, and immune recognition. In contrast, glycosylation of bacteriophage particles has not been reported; phage virions typically do not...
6.
Dedrick R, Freeman K, Nguyen J, Bahadirli-Talbott A, Cardin M, Cristinziano M, et al.
Open Forum Infect Dis . 2022 Jul; 9(7):ofac194. PMID: 35794944
An elderly man with refractory lung disease previously developed anti-phage neutralizing antibodies while receiving intravenous phage therapy. Subsequent phage nebulization resulted in transient weight gain, decreased C-reactive protein, and reduced...
7.
Dedrick R, Smith B, Cristinziano M, Freeman K, Jacobs-Sera D, Belessis Y, et al.
Clin Infect Dis . 2022 Jun; 76(1):103-112. PMID: 35676823
Background: Nontuberculous Mycobacterium infections, particularly Mycobacterium abscessus, are increasingly common among patients with cystic fibrosis and chronic bronchiectatic lung diseases. Treatment is challenging due to intrinsic antibiotic resistance. Bacteriophage therapy...
8.
Nick J, Dedrick R, Gray A, Vladar E, Smith B, Freeman K, et al.
Cell . 2022 May; 185(11):1860-1874.e12. PMID: 35568033
Two mycobacteriophages were administered intravenously to a male with treatment-refractory Mycobacterium abscessus pulmonary infection and severe cystic fibrosis lung disease. The phages were engineered to enhance their capacity to lyse...
9.
Little J, Dedrick R, Freeman K, Cristinziano M, Smith B, Benson C, et al.
Nat Commun . 2022 May; 13(1):2313. PMID: 35504908
Mycobacterium chelonae is a rare cause of chronic disseminated cutaneous infections in immunocompromised patients. Multidrug-resistant M. chelonae infections present a challenge for treatment, and prolonged antimicrobial courses lead to significant...
10.
Freeman K, Wetzel K, Zhang Y, Zack K, Jacobs-Sera D, Walters S, et al.
Microorganisms . 2021 Dec; 9(12). PMID: 34946016
The explosion of SARS-CoV-2 infections in 2020 prompted a flurry of activity in vaccine development and exploration of various vaccine platforms, some well-established and some new. Phage-based vaccines were described...