Kosuke Watari
Overview
Explore the profile of Kosuke Watari including associated specialties, affiliations and a list of published articles.
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Articles
39
Citations
1142
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Recent Articles
1.
Gu L, Zhu Y, Nandi S, Lee M, Watari K, Bareng B, et al.
Nature
. 2025 Jan;
638(8051):E30.
PMID: 39890899
No abstract available.
2.
Zhang P, Watari K, Karin M
Nat Immunol
. 2025 Jan;
26(1):29-41.
PMID: 39747429
A slew of common metabolic disorders, including type 2 diabetes, metabolic dysfunction-associated steatotic liver disease and steatohepatitis, are exponentially increasing in our sedentary and overfed society. While macronutrients directly impact...
3.
Gu L, Zhu Y, Nandi S, Lee M, Watari K, Bareng B, et al.
Nature
. 2025 Jan;
637(8045):461-469.
PMID: 39743585
Hepatocellular carcinoma (HCC) originates from differentiated hepatocytes undergoing compensatory proliferation in livers damaged by viruses or metabolic-dysfunction-associated steatohepatitis (MASH). While increasing HCC risk, MASH triggers p53-dependent hepatocyte senescence, which we...
4.
Zhang P, Liu J, Lee A, Tsaur I, Ohira M, Duong V, et al.
Cell Metab
. 2024 Sep;
36(10):2341-2354.e6.
PMID: 39317186
The exponential rise in metabolic dysfunction-associated steatotic liver disease (MASLD) parallels the ever-increasing consumption of energy-dense diets, underscoring the need for effective MASLD-resolving drugs. MASLD pathogenesis is linked to obesity,...
5.
Gu L, Zhu Y, Watari K, Lee M, Liu J, Perez S, et al.
Cell Metab
. 2023 Apr;
35(6):1009-1021.e9.
PMID: 37084733
Insulin inhibits gluconeogenesis and stimulates glucose conversion to glycogen and lipids. How these activities are coordinated to prevent hypoglycemia and hepatosteatosis is unclear. Fructose-1,6-bisphosphatase (FBP1) is rate controlling for gluconeogenesis....
6.
Xian H, Watari K, Sanchez-Lopez E, Offenberger J, Onyuru J, Sampath H, et al.
Immunity
. 2022 Jul;
55(8):1370-1385.e8.
PMID: 35835107
Mitochondrial DNA (mtDNA) escaping stressed mitochondria provokes inflammation via cGAS-STING pathway activation and, when oxidized (Ox-mtDNA), it binds cytosolic NLRP3, thereby triggering inflammasome activation. However, it is unknown how and...
7.
Murakami Y, Kusakabe D, Watari K, Kawahara A, Azuma K, Akiba J, et al.
Sci Rep
. 2022 Jun;
12(1):8983.
PMID: 35643725
Osimertinib, a third-generation EGFR-TKI, has nowadays been applied to non-small cell lung cancer harboring activated EGFR mutation with or without T790M, but ultimately develop resistance to this drug. Here we...
8.
Sato M, Fuchida H, Shindo N, Kuwata K, Tokunaga K, Xiao-Lin G, et al.
ACS Med Chem Lett
. 2020 Jun;
11(6):1137-1144.
PMID: 32550993
Covalent modification of disease-associated proteins with small molecules is a powerful approach for achieving an increased and sustained pharmacological effect. To reduce the potential risk of nonselective covalent modification, molecular...
9.
Watari K, Shibata T, Fujita H, Shinoda A, Murakami Y, Abe H, et al.
Commun Biol
. 2020 Mar;
3(1):107.
PMID: 32144393
Many diseases, including cancer, have been associated with impaired regulation of angiogenesis, of which vascular endothelial growth factor (VEGF)-A is a key regulator. Here, we test the contribution of N-myc...
10.
Shibata T, Watari K, Kawahara A, Sudo T, Hattori S, Murakami Y, et al.
Mol Cancer Ther
. 2019 Dec;
19(3):882-894.
PMID: 31879363
Nuclear expression of Y-box-binding protein (YBX1) is closely correlated with clinical poor outcomes and drug resistance in breast cancer. Nuclear translocation of YBX1 is facilitated by YBX1 phosphorylation at serine...