Koji Toshinai
Overview
Explore the profile of Koji Toshinai including associated specialties, affiliations and a list of published articles.
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43
Citations
1421
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Recent Articles
1.
Tanida R, Tsubouchi H, Yanagi S, Saito Y, Toshinai K, Miyazaki T, et al.
Biochem Biophys Res Commun
. 2021 Dec;
589:260-266.
PMID: 34929449
Acute respiratory distress syndrome (ARDS) is a critical illness syndrome characterized by dysregulated pulmonary inflammation. Currently, effective pharmacological treatments for ARDS are unavailable. Ghrelin, an endogenous ligand for the growth...
2.
Functional interaction between Ghrelin and GLP-1 regulates feeding through the vagal afferent system
Zhang W, Waise T, Toshinai K, Tsuchimochi W, Naznin F, Islam M, et al.
Sci Rep
. 2020 Oct;
10(1):18415.
PMID: 33116243
The gastrointestinal tract transmits feeding-regulatory signals to the brain via neuronal and hormonal pathways. Here we studied the interaction between the orexigenic gastric peptide, ghrelin, and the anorectic intestinal peptide,...
3.
Okada T, Waise T, Toshinai K, Mita Y, Sakoda H, Nakazato M
Neurosci Lett
. 2018 May;
681:50-55.
PMID: 29802915
The vagus nerve connects peripheral organs to the central nervous system (CNS), and gastrointestinal hormones transmit their signals to the CNS via the vagal afferent nerve. Ghrelin, a gastric-derived orexigenic...
4.
Naznin F, Toshinai K, Waise T, Okada T, Sakoda H, Nakazato M
J Mol Endocrinol
. 2017 Dec;
60(2):109-118.
PMID: 29233861
High-fat diet (HFD)-induced metabolic inflammation in the central and peripheral organs contributes to the pathogenesis of obesity. Long-term HFD blunts signaling by ghrelin, a gastric-derived orexigenic peptide, in the vagal...
5.
NamKoong C, Toshinai K, Waise T, Sakoda H, Sasaki K, Ueta Y, et al.
Biochem Biophys Res Commun
. 2017 Feb;
485(2):409-413.
PMID: 28213131
Neuroendocrine regulatory peptide (NERP)-2 is derived from a distinct region of VGF, a neurosecretory protein originally identified as a product of a nerve growth factor-responsive gene in rat PC12 cells....
6.
Kimura K, Tanida M, Nagata N, Inaba Y, Watanabe H, Nagashimada M, et al.
Cell Rep
. 2016 Mar;
14(10):2362-74.
PMID: 26947072
Central insulin action activates hepatic IL-6/STAT3 signaling, which suppresses the gene expression of hepatic gluconeogenic enzymes. The vagus nerve plays an important role in this centrally mediated hepatic response; however,...
7.
Waise T, Toshinai K, Naznin F, NamKoong C, Moin A, Sakoda H, et al.
Biochem Biophys Res Commun
. 2015 Jul;
464(4):1157-1162.
PMID: 26208455
A high-fat diet (HFD) induces inflammation in systemic organs including the hypothalamus, resulting in obesity and diabetes. The vagus nerve connects the visceral organs and central nervous system, and the...
8.
Naznin F, Toshinai K, Waise T, NamKoong C, Moin A, Sakoda H, et al.
J Endocrinol
. 2015 May;
226(1):81-92.
PMID: 26016745
Ghrelin, a stomach-derived orexigenic peptide, transmits starvation signals to the hypothalamus via the vagus afferent nerve. Peripheral administration of ghrelin does not induce food intake in high fat diet (HFD)-induced...
9.
Toshinai K, Saito T, Yamaguchi H, Sasaki K, Tsuchimochi W, Minamino N, et al.
Brain Res
. 2014 Apr;
1563:52-60.
PMID: 24704271
Neuroendocrine regulatory peptide (NERP)-1 and NERP-2 (NERPs) are novel carboxy-terminally amidated peptides derived from the neurosecretory protein VGF. NERPs are colocalized with vasopressin in the paraventricular nucleus (PVN) and the...
10.
Yano Y, Nakazato M, Toshinai K, Inokuchi T, Matsuda S, Hidaka T, et al.
Am J Hypertens
. 2013 Dec;
27(5):727-33.
PMID: 24363280
Background: We aimed to assess the predictive value of circulating levels of des-acyl ghrelin, an abundant form of ghrelin in humans, for the risk of cardiovascular disease (CVD) in older...