Koji Onomoto
Overview
Explore the profile of Koji Onomoto including associated specialties, affiliations and a list of published articles.
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Articles
33
Citations
1332
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Recent Articles
1.
Shibata K, Moriizumi H, Onomoto K, Kaneko Y, Miyakawa T, Zenno S, et al.
Nucleic Acids Res
. 2024 Apr;
52(9):5209-5225.
PMID: 38636948
RNA silencing is a post-transcriptional gene-silencing mechanism mediated by microRNAs (miRNAs). However, the regulatory mechanism of RNA silencing during viral infection is unclear. TAR RNA-binding protein (TRBP) is an enhancer...
2.
Im J, Duic I, Yoshimura S, Onomoto K, Yoneyama M, Kato H, et al.
Sci Rep
. 2024 Jan;
14(1):835.
PMID: 38191794
No abstract available.
3.
Im J, Duic I, Yoshimura S, Onomoto K, Yoneyama M, Kato H, et al.
Sci Rep
. 2023 Apr;
13(1):6318.
PMID: 37072508
Retinoic acid-inducible gene I (RIG-I) is the most front-line cytoplasmic viral RNA sensor and induces antiviral immune responses. RIG-I recognizes short double-stranded (dsRNA) (< 500 bp), but not long dsRNA...
4.
Kojima I, Onomoto K, Zuo W, Ozawa M, Okuya K, Naitou K, et al.
J Virol
. 2022 Sep;
96(18):e0081022.
PMID: 36069552
Stress granules (SGs) are dynamic structures that store cytosolic messenger ribonucleoproteins. SGs have recently been shown to serve as a platform for activating antiviral innate immunity; however, several pathogenic viruses...
5.
Hayashi Y, Suzuki H, Nakajima W, Uehara I, Tanimura A, Himeda T, et al.
PLoS One
. 2021 Nov;
16(11):e0260443.
PMID: 34843580
Although sensorineural hearing loss (SHL) is relatively common, its cause has not been identified in most cases. Previous studies have suggested that viral infection is a major cause of SHL,...
6.
Onomoto K, Onoguchi K, Yoneyama M
Cell Mol Immunol
. 2021 Jan;
18(3):539-555.
PMID: 33462384
Retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) are RNA sensor molecules that play essential roles in innate antiviral immunity. Among the three RLRs encoded by the human genome, RIG-I and...
7.
Hayashi Y, Suzuki H, Nakajima W, Uehara I, Tanimura A, Himeda T, et al.
Sci Rep
. 2020 Apr;
10(1):6740.
PMID: 32317718
To protect the audiosensory organ from tissue damage from the immune system, the inner ear is separated from the circulating immune system by the blood-labyrinth barrier, which was previously considered...
8.
Takahashi T, Nakano Y, Onomoto K, Yoneyama M, Ui-Tei K
Nucleic Acids Res
. 2019 Dec;
48(3):1494-1507.
PMID: 31799626
During viral infection, viral nucleic acids are detected by virus sensor proteins including toll-like receptor 3 or retinoic acid-inducible gene I-like receptors (RLRs) in mammalian cells. Activation of these virus...
9.
Takahasi K, Onomoto K, Horiuchi M, Kato H, Fujita T, Yoneyama M
Biochem Biophys Res Commun
. 2019 Aug;
517(4):662-669.
PMID: 31395337
Upon viral infection, retinoic acid-inducible gene-I (RIG-I)-like receptors detect viral foreign RNAs and transmit anti-viral signals via direct interaction with the downstream mitochondrial adaptor molecule, interferon (IFN)-β promoter stimulator-1 (IPS-1),...
10.
Ohto T, Konishi M, Tanaka H, Onomoto K, Yoneyama M, Nakai Y, et al.
Biol Pharm Bull
. 2019 Feb;
42(2):299-302.
PMID: 30713260
While the use of in vitro-transcribed mRNA (IVT-mRNA) in therapeutics is a rapidly expanding area, the transfection of the exogenous IVT-mRNA is accompanied by a risk of immune activation. This...